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The Italian Journal of Medicine (ITJM) is the official journal of FADOI, the Federation of Associations of Hospital Doctors on Internal Medicine and focus to describe the complex and variable situations confronted by Internists in daily practice. ITJM aims to promote excellence in the practice of internal medicine in hospitals and to disseminate the results of clinical research in internal medicine departments. The journal also contributes to the updating of hospital internists on general topics concerning public health, including ethical, legal, economical and health policy issues. The Journal includes original clinical research papers, reviews, case reports and specific sections dedicated to clinical pharmacology, chronic diseases, health management. ITJM is currently indexed in Web of Science/ESCI, Scopus and DOAJ since September 2009.

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New Articles

• A “cold” case of myxedema coma

  Elisa Eletto, Carmine Siniscalchi, Nicoletta Cerundolo, Beatrice Prati, Lorenzo Finardi, Riccardo Simoni, Alberto Parise, Antonio Nouvenne, Tiziana Meschi

  https://doi.org/10.4081/itjm.2025.1999

  22

  PDF: 18

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• Impact of tumor necrosis factor-α and interleukin 6 polymorphisms on type 2 diabetes mellitus Sudanese patients

  Elmutuz H. Elssaig, Abdalla Eltoum Ali, Mohammed A. Alsubai, Tarig M.S. Alnour, Eltayib H. Ahmed-Abakur, Aadil Yousif, Bashayr Mudhhi Alshehri, Fatmah Ali Awaji, Arwa Murdi Alanazi, Fai Fahad Alanazi, Abdullah Ali Alghamdi

  https://doi.org/10.4081/itjm.2025.1967

  38

  PDF: 17

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• First-level clinical point-of-care ultrasound: an essential tool for today’s internist

  Mauro Silingardi, Nicola Mumoli, Emanuela Laurita, Elisa Romagnoli, Giovanna Casoli, Stefania Marengo, Federica Agrusta, Marinella Tricarico, Luisa Arnaldi, Giovanni Gardini, Francesco Dentali

  https://doi.org/10.4081/itjm.2025.1939

  124

  PDF: 33

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• Employing the European Thyroid Imaging Reporting and Data System 2017 classification in a malignancy risk stratification system for thyroid nodules at Can Tho Oncology Hospital from 2021 to 2023

  Vo Van Kha, Tran Thi Huong Ly, Pham Thi Thanh Hoa, Vo Huynh Nhu

  https://doi.org/10.4081/itjm.2025.1852

  315

  PDF: 68

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• Metformin’s therapeutic potential in adenomyosis: insights from interleukin 8 level

  Damas Hendriansyah, Nusratuddin Abdullah, Rudy B. Leonardy, Mardiah Tahir, Samrichard Rambulangi, Firdaus Hamid

  https://doi.org/10.4081/itjm.2025.1940

  280

  PDF: 54

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• An innovative model of university cooperation in developing countries: results of five years of experience in internal medicine, health promotion and education

  Filomena Pietrantonio, Vera Kopsaj, Francesco Rosiello, Aurora Tomassoni, Luca Moriconi, Donatella Padua

  https://doi.org/10.4081/itjm.2025.1941

  240

  PDF: 69

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• When should antihypertensive drug treatment be started? Discrepancies between the 2023 European Society of Hypertension and the 2024 European Society of Cardiology guidelines

  Giuseppe Mancia, Guido Grassi, Sverre E. Kjeldsen

  https://doi.org/10.4081/itjm.2025.1981

  337

  PDF: 92

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• Correlation between neutrophils-to-lymphocyte ratio and soluble FMS-like tyrosine kinase 1 in pregnant women with preeclampsia

  Kiki Rizki Amelia, Efendi Lukas, Nurbani Bangsawan, Isharyah Sunarno, Retno Budiarti Farid, Sriwijaya Qadar

  https://doi.org/10.4081/itjm.2025.1924

  220

  PDF: 51

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• Intermediate care units in internal medicine: the case of Apulia

  Francesco Ventrella, Anna Belfiore, Antonio Greco, Franco Mastroianni, Salvatore Lenti, Domenico Ruggiero, Michele Cannone, Vincenzo Ostilio Palmieri, Massimo Errico

  https://doi.org/10.4081/itjm.2025.1960

  315

  PDF: 107

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• Gender differences and post-pandemic mental health impacts: a mediation study on Vietnamese adolescents

  Thanh Long Nguyen, Victor Storm, Lam Toi Phung, Cong Thien Le, Thi Thu Ha Le, Thi Hoa Nguyen, Son Tung Vu, Thien Thang Tran, Minh Hanh Vu, Van Tuan Nguyen

  https://doi.org/10.4081/itjm.2025.1888

  273

  PDF: 108

  SUPPLEMENTARY MATERIAL: 37

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• Peritoneal involvement in acute pericarditis with polyserositis may mimic acute cholecystitis: a case report

  Emanuele Bizzi, Francesco Moda, Massimo Pancrazi, Alice Pedroli, Ruggiero Mascolo, Antonio Luca Brucato

  https://doi.org/10.4081/itjm.2025.1931

  232

  PDF: 95

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• Mentzer Index and Red Cell Distribution Width Index in differentiating iron deficiency anemia and β-thalassemia trait

  Rabab H. Elshaikh, Ashok Kumar Sah, Abdelrahman Mohamed Abukanna, Abdulrahman Algarni, Ammar Abdelmola, Hussam Ali Osman, Tagwa Yousif Elsayed Yousif, Elryah I. Ali, Hiba Ali, Ayman Hussein Alfeel

  https://doi.org/10.4081/itjm.2025.1892

  539

  PDF: 87

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• Cytokine profile in COVID-19 infection: focus on interleukin-13, interleukin-33, and tumor necrosis factor-α as immunological markers

  Huda Saleem, Wafaa Hazim, Batool Mutar Mahdi, Mohammed S. Al-Iedani

  https://doi.org/10.4081/itjm.2025.1823

  245

  PDF: 124

  SUPPLEMENTARY MATERIAL: 36

  HTML: 17

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• The man from the stars: a narrative approach to neglected diseases

  Paolo Agostinis, Teresa Michelutti, Laura Iogna Prat, Omar Simonetti

  https://doi.org/10.4081/itjm.2025.1900

  179

  PDF: 75

  HTML: 11

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• The role of genetic variations in metabolic syndrome: insights into etiology, diagnosis, and management

  Darla Srinivasa Rao, Ajay Kumar, Shagun Agarwal, Rabab Hassan Elshaikh, AjabSingh Choudhary, Ranjay Kumar Choudhary, Assad M A Babker, Rohit Rathore, Zhannat Nurmakhanova, Zhanar Nurgaliyeva, Abdugani Musayev, Ashok Kumar Sah

  https://doi.org/10.4081/itjm.2025.1908

  571

  PDF: 196

  HTML: 21

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• Embracing artificial intelligence in internal medicine: a tool for physicians and patients

  Matteo Giorgi-Pierfranceschi

  https://doi.org/10.4081/itjm.2025.1791

  321

  PDF: 78

  HTML: 4

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• Immunohistochemical expression of transient receptor potential vanilloid 1 in World Health Organization grade IV astrocytoma, oral squamous cell carcinoma and bladder carcinoma

  Imrana Tanvir, Samina Qamar, Ahmad Alwazzan, Khurram Mehboob, Yousef Almehmadi, Ebtihal Ali Alharbi, Shadi Ahmed Alahmadi, Hafsa Adnan

  https://doi.org/10.4081/itjm.2025.1893

  262

  PDF: 119

  HTML: 16

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• Effect of magnesium and potassium on rheumatoid arthritis factor and quality of life in patients with type 2 diabetes mellitus: a randomized control trial

  Hafiza Sonia Bibi, Uzma Rafi, Sidra Khalid, Riffat Mehboob, Anbreen Bibi, Hani Sadaka Shalabi, Mohammed A. Zaher, Samy A. Abusikkien

  https://doi.org/10.4081/itjm.2025.1874

  440

  PDF: 117

  HTML: 13

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• La sindrome cardio-nefro-metabolica

  Andrea Montagnani, Dario Manfellotto

  1-38

  https://doi.org/10.4081/itjm.q.2025.1

  218

  PDF: 270

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• Diagnostic and therapeutic care pathway of the Cardiac Network for Heart Failure

  Pasquale Palmiero, Matteo Durante, Maria Maiello, Valentina D’Andria, Cosima Caputo, Lucia Giordano

  https://doi.org/10.4081/itjm.2025.1927

  445

  PDF: 112

  HTML: 18

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• A toothpick man user with COVID-19

  Francesco Serafini, Elia Vettore, Fabio Presotto

  https://doi.org/10.4081/itjm.2025.1897

  254

  PDF: 83

  HTML: 12

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• CO-St (COVID 19-study): sex differences in the treatment of COVID-19

  Manuel Monti, Tiziana Ciarambino, Filomena Pietrantonio, Sara Rotunno, Alessandra Fiorentini, Rosalba Cipriani, Giuseppe Campagna, Giuseppe Straface, Eleonora Pistella, Mauro Giordano, Orazio Valerio Giannico, Roberto Marchetti, Federica Lorenzi, Francesco Rosiello

  https://doi.org/10.4081/itjm.2025.1916

  338

  PDF: 119

  HTML: 1

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• Visceral leishmaniasis and lymphoma: a rare and dangerous couple

  Nicola Battino, Antonio Pisano

  https://doi.org/10.4081/itjm.2025.1843

  231

  PDF: 100

  HTML: 1

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• Evaluation of the renal function among sickle cell patients: a cross-sectional study

  Talal Qadah, Anwar Refaei

  https://doi.org/10.4081/itjm.2025.1868

  249

  PDF: 129

  SUPPLEMENTARY MATERIAL: 32

  HTML: 12

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• Virus-induced asthma exacerbations in Vietnamese preschoolers

  Nguyen Thuy Van Thao, Tran Anh Tuan, Pham Hung Van, Le Thuong Vu

  https://doi.org/10.4081/itjm.2025.1818

  204

  PDF: 98

  HTML: 6

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• Acute kidney failure due to varicella-zoster virus solved by early antiviral treatment based on brivudin

  Fulvia Paolozzi, Pierpaolo Di Micco, Antonella Giliberti, Gianluca Latte, Maria Teresa Feola, Immacolata Gaia Paduano, Concetta Schiano, Maurizio Latte

  https://doi.org/10.4081/itjm.2025.1786

  255

  PDF: 145

  HTML: 14

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• Serum transferrin level in type-2 diabetic patients in association with sociodemographic profile and dietary habits

  Anza Khan, Uzma Rafi, Riffat Mehboob, Sajid Hameed, Uzma Malik, Zainab Zubair, Imran Shahid

  https://doi.org/10.4081/itjm.2025.1873

  314

  PDF: 160

  HTML: 15

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• The incidence of bleeding in patients with nonvalvular atrial fibrillation using anticoagulants: a real-world report with the biggest Vietnamese data

  Bui The Dung, Cao Ngoc Mai Han, Tran Hoa, Nguyen Thanh Hien

  https://doi.org/10.4081/itjm.2025.1807

  1758

  PDF: 165

  HTML: 1

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• An algorithm for the management of chronic obstructive pulmonary disease patients in units of internal medicine

  Ombretta Para, Carmen Stabile, Donato Cinquepalmi, Maria Sandra Magnoni, Francesco Nasso, Flavio Tangianu, Mauro Silingardi, Antonella Valerio, Dario Manfellotto, Francesco Dentali

  https://doi.org/10.4081/itjm.2025.1838

  676

  PDF: 969

  HTML: 20

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• The unseen connection: laryngeal carcinoma and thrombosis of the internal jugular vein

  Laura Leci-Tahiri, Lisa Tahiri, Valbona Zhjeqi, Emina Ramku

  https://doi.org/10.4081/itjm.2025.1882

  1660

  PDF: 103

  HTML: 20

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• Predictive value of Frank’s sign for obstructive coronary artery disease confirmed by coronary computed tomography angiography

  Truong Phi Hung, Nguyen Minh Kha, Dang Tuong Vi, Tran Trong Nhan, Hoang Van Sy

  https://doi.org/10.4081/itjm.2025.1863

  1822

  PDF: 217

  SUPPLEMENTARY MATERIAL: 48

  HTML: 26

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• Right ventricular failure due to subacute massive pulmonary embolism

  Claudio Giumelli, Giacomo Bussolati, Patricia Granauro, Paolo Montanari

  https://doi.org/10.4081/itjm.2025.1747

  1365

  PDF: 152

  VIDEO 1: 89

  HTML: 14

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• First evidence of immunomodulation of the renin-angiotensin system through substance P/neurokinin 1 receptor: a case and control study in hypertension and cardiac patients

  Ibrahim M. Alanazi, Riffat Mehboob, Ayesha Tariq, Sajid Hameed, Uzma Malik, Noreen Sarwar, Imran Shahid, Khurram Mehboob

  https://doi.org/10.4081/itjm.2025.1870

  1087

  PDF: 428

  HTML: 11

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• Maternal, fetal, and perinatal outcomes of COVID-19-infected pregnancies in Saudi Arabia: a meta-analysis and systematic review

  Ahmad Alwazzan

  https://doi.org/10.4081/itjm.2025.1877

  820

  PDF: 389

  HTML: 10

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• Exploring the determinants of exclusive breastfeeding among postpartum women in northeastern Morocco: fathers’ knowledge as a moderating factor

  Khalid Faraj, Abdellatif Bour

  https://doi.org/10.4081/itjm.2025.1861

  558

  PDF: 423

  HTML: 3

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• Early and late outcomes of emergency coronary bypass grafting in non-ST-segment elevation acute myocardial infarction

  Nguyen Thai Minh, Nguyen Sinh Hien, Bui The Dung, Doan Quoc Hung

  https://doi.org/10.4081/itjm.2025.1808

  740

  PDF: 418

  HTML: 151

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• C-reactive protein as a diagnostic marker for ovarian carcinoma

  Angga Dewi Umar Wahyu, Syahrul Rauf, Susiawaty Susiawaty, Maisuri T. Chalid, Nugraha Utama Pelupessy, Irma Savitri

  https://doi.org/10.4081/itjm.2025.1819

  815

  PDF: 263

  HTML: 27

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• Role of platelet indices and vitamin D in forecasting deterioration of glycemic control and vascular complications in type 2 diabetes

  Maryam Ahmed Obaid Al Ali, Khalid Abdelsamea Mohamedahmed, Asaad Ma Babker

  https://doi.org/10.4081/itjm.2025.1875

  816

  PDF: 274

  HTML: 26

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• Skin lesions and the role of the internist: a series of clinical cases

  Carolina Bologna, Domenico Birra, Marina Lugarà, Antonietta De Sena, Gabriella Oliva, Paolo Tirelli, Pasquale Madonna, Vincenzo Nuzzo

  https://doi.org/10.4081/itjm.2024.1796

  1106

  PDF: 256

  HTML: 1

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• Stochastic Petri net model with random time of Vietnamese ischemic stroke patient treatment process

  Nguyen Tien Dung, Nguyen-Thi Phuong Quynh, Ho Cam Tu, Bui-Thi Thu Huong, Pham-Thi Thuy, Vu-Thi Hoai Thu, Lo Minh Trong, Ho Khanh Lam, Nguyen Phuong Sinh

  https://doi.org/10.4081/itjm.2024.1806

  1114

  PDF: 298

  HTML: 3

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• Obesity: a potential cause of varicocele leading to male infertility

  Zain ul Hasan, Syed Amir Gilani, Asif Hanif, Raham Bacha, Zareen Fatima

  https://doi.org/10.4081/itjm.2024.1827

  1152

  PDF: 206

  HTML: 1

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• Profile of dietary supplement consumers in the region of Rabat-Salé-Kénitra, Morocco

  Oumaima Touijri, Btihaj Al Ibrahmi, Yassmine Nahab, Ali Quyou, Moulay Laarbi Ouahidi

  https://doi.org/10.4081/itjm.2024.1857

  887

  PDF: 260

  HTML: 5

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• Screening of the key genes and signaling pathways for schizophrenia using bioinformatics and next generation sequencing data analysis

  Iranna Kotturshetti, Basavaraj Vastrad, Veena Kori, Chanabasayya Vastrad, Shivakumar Kotrashetti

  https://doi.org/10.4081/itjm.2024.1830

  1535

  PDF: 322

  SUPPLEMENTARY MATERIAL: 166

  HTML: 15

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• Assessment of the knowledge of pregnant women with gestational diabetes regarding diet and physical activity in Morocco

  Hanane Azargui, Btihaj AL Ibrahmi, Abdellatif Bour

  https://doi.org/10.4081/itjm.2024.1849

  989

  PDF: 274

  HTML: 23

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• Retrieving the information stored in the donated organ may cause the patient’s personality to change after the transplant operation

  Jamal Al-Karaki, Muhammad Al-Zafar Khan, Phoka Rathebe, Raul Valverde, Alireza Sepehri, Massimo Fioranelli

  https://doi.org/10.4081/itjm.2024.1790

  854

  PDF: 299

  HTML: 27

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• Is a terminally ill non-cancer patient really forced to stay at the hospital?

  Francesco Serafini, Maria Gabriella Procacci, Elia Vettore, Giulia Cardinali, Fabio Presotto

  https://doi.org/10.4081/itjm.2024.1850

  709

  HTML: 29

  PDF: 265

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• La medicina perioperatoria e il co-management medico-chirurgico: position paper FADOI-ACOI In collaborazione con SISET, SIMIT, SIN, SINPE

  Davide Carrara, Francesco Dentali

  1-48

  https://doi.org/10.4081/itjm.q.2024.7

  791

  PDF: 810

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• The importance of the cardiology observation unit in the management of patients with cardiovascular diseases: a pilot project

  Manuel Monti, Simone Cappannelli, Marco Cardile, Deborah Cosmi, Tania Di Pasquale, Mariana Cappannelli, Jacopo Fagotti, Pietro Quadalti, Michele Marvardi, Roberto Marchetti, Euro Capponi

  https://doi.org/10.4081/itjm.2024.1840

  835

  PDF: 317

  HTML: 40

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• Safety and efficacy of renal denervation utilizing standard bidirectional EP catheter: preliminary Vietnamese findings

  Tran Ba Hieu, Nguyen Ngoc Quang, Pham Manh Hung

  https://doi.org/10.4081/itjm.2024.1816

  833

  PDF: 365

  HTML: 93

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• Vitamin D and intrauterine growth restriction: a cross-sectional study

  Fadhilah Arnan, Maisuri T. Chalid, Monika Fitria Farid, Efendi Lukas, Ellen Wewengkang

  https://doi.org/10.4081/itjm.2024.1833

  1004

  PDF: 376

  HTML: 111

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