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The Italian Journal of Medicine (ITJM) is the official journal of FADOI, the Federation of Associations of Hospital Doctors on Internal Medicine and focus to describe the complex and variable situations confronted by Internists in daily practice. ITJM aims to promote excellence in the practice of internal medicine in hospitals and to disseminate the results of clinical research in internal medicine departments. The journal also contributes to the updating of hospital internists on general topics concerning public health, including ethical, legal, economical and health policy issues. The Journal includes original clinical research papers, reviews, case reports and specific sections dedicated to clinical pharmacology, chronic diseases, health management. ITJM is currently indexed in Web of Science/ESCI, Scopus and DOAJ since September 2009.

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New Articles

• Primary aldosteronism unmasked during pregnancy: a case report

  Antonio Concistrè, Claudia Caramazza, Marco D’Abbondanza, Giuseppe Imperoli

  https://doi.org/10.4081/itjm.2025.1949

  126

  PDF: 25

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• Challenges and evolution of the Italian National Health Service: between crisis and reform

  Pierpaolo Di Micco, Egidio Imbalzano, Carmine Siniscalchi

  https://doi.org/10.4081/itjm.2025.2100

  97

  PDF: 26

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• The effect of type 2 diabetes mellitus on clinical symptoms, sputum molecular test results, and lesions in thoracic photos of pulmonary tuberculosis patients

  Fikriatul Fadhilah, Erwin Arief, Nur Ahmad Tabri, Irawaty Djaharuddin, Arif Santoso, Jamaluddin Madolangan

  https://doi.org/10.4081/itjm.2025.2048

  117

  PDF: 36

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• Role of sodium-glucose cotransporter 2 inhibitors in cardiovascular events in patients with heart failure

  Eva Muja, Letizia Giuseppina Floccari, Artan Simaku, Klodeta Grosha, Besim Lama, Ilirian Laçi

  https://doi.org/10.4081/itjm.2025.1997

  217

  PDF: 68

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• Risk factors for colorectal cancer in Albania: a case-control study

  Marsela Sina, Skerdi Prifti, Adea Kocollari, Ilir Akshija, Dorina Osmanaj, Gentiana Qirjako

  https://doi.org/10.4081/itjm.2025.2007

  136

  PDF: 49

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• The parental challenge: knowledge, attitudes, and practices on iron deficiency anemia in Tabuk

  Sawsan Mohammed Alblewi, Amerah M Alatawi, Faisal Mayudh Althobaiti, Adel Ali Alharfi, Faisal Mohammed Alamrani, Yazeed Mahmoud Ajwah, Omar Muslih Albalawi, Mohammed Majed Alquayr, Ariam Ebraheem Alshammari

  https://doi.org/10.4081/itjm.2025.1946

  163

  PDF: 51

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• Utility of the aspirin and P2Y12 response assays to determine the effects of antiplatelet agents in patients with subdural hematoma undergoing neurosurgery

  Ombretta Para, Christian Carleo, Francesco Bucci, Lucia Lipari, Asim Raza, Edoardo Cesaroni, Chiara La Rovere, Simone Orlandini, Gastone Pansini, Alberto Parenti, Giovanni Muscas, Alessandro Della Puppa

  https://doi.org/10.4081/itjm.2025.1926

  300

  PDF: 52

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• Perceived stress in parents of children with neurodevelopmental disorders: psychometric properties of the stress measurement scale in the Moroccan dialect

  Sara Alouane, Zakaria Abidli, Ahmed O.T. Ahami, Soukaina El Idrissi, Jamila Riyahi

  https://doi.org/10.4081/itjm.2025.1991

  162

  PDF: 72

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• Age diversity management in healthcare: leveraging generational differences with an inclusive approach

  Filomena Pietrantonio, Giulia Brunelli, Gabriele Angelo Vassallo, Luca Moriconi, Alessandro Signorini, Andrea Moriconi

  https://doi.org/10.4081/itjm.2025.2074

  240

  PDF: 100

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• Differential diagnosis of prion diseases in the vast chapter of degenerative encephalopathies, a challenge for the internist: two case reports compared

  Filomena Pietrantonio, Angela Ciamei, Gabriele Angelo Vassallo, Luca Moriconi, Margherita Lordi

  https://doi.org/10.4081/itjm.2025.2075

  167

  PDF: 64

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• The future of diagnostics: cutting-edge advances in healthcare technology

  Ashok Kumar Sah, Darla Srinivasa Rao, Anass M Abbas, M Chandrasekar, Mohamed Ahmed Mohamed Adam, Ajab Singh Choudhary, Ranjay Kumar Choudhary, Rabab H. Elshaikh, Pranav Kumar Prabhakar, Syrsulu Myrzagulova, Rohit Rathore, Asaad M. Babker, Devendra Prasad, Shagun Agarwal

  https://doi.org/10.4081/itjm.2025.1932

  428

  PDF: 67

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• Association between 25-hydroxy vitamin D insufficiency and serum uric acid levels compared to the gender and age categories

  Salah Eldin Omar Hussein, Awadh S. Alsubhi, Abdulrahman Algarni, Elryah I. Ali, Tagwa Yousif Elsayed Yousif, Ammar Abdelmola, Elyasa Elfaki, Wael Alzahrani, Ayman Hussien Alfeel

  https://doi.org/10.4081/itjm.2025.2029

  283

  PDF: 73

  HTML: 4

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• A case report of bladder cancer-related acquired hemophilia A

  Gaia Dragoni, Nicolò Ferraroni, Raffaella Benedetti, Aderville Cabassi, Davide Imberti

  https://doi.org/10.4081/itjm.2025.2019

  198

  PDF: 99

  HTML: 7

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• Correlation of circulating diabetes markers with elevated serum antithyroglobulin antibodies in type 2 diabetes patients

  Batool Ibrahim Aljasmmi, Awadh S Alsubhi, Abdulrahman Algarni, Elryah I Ali, Ammar Abdelmola, Hussam Ali Osman, Abdelrahman Mohamed Ahmed Abukanna, Marwan Ismail, Asaad Babker, Salah Eldin Omar Hussein

  https://doi.org/10.4081/itjm.2025.1961

  262

  PDF: 59

  HTML: 9

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• Minimally invasive versus median sternotomy for mechanical mitral valve replacement: a single-center comparative study of treatment outcomes and quality of life

  The Binh Nguyen, Tran-Thuy Nguyen, Long Hoang Luong, Duc Hoang Nguyen, Cong Huu Nguyen, Ngoc Thanh Le, Bao Giang Kim

  https://doi.org/10.4081/itjm.2025.1963

  545

  PDF: 104

  HTML: 0

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• The role of the neutrophil-to-lymphocyte ratio and the platelet-to-lymphocyte ratio in assessing hypothyroidism Hashimoto’s thyroiditis

  Ruqeya Murad, Ayman H. Alfeel, Zulekha Shemote, Praveen Kumar, Asaad Babker, Ahmed Luay Osman, Abdelgdair A. Altoum

  https://doi.org/10.4081/itjm.2025.1953

  480

  PDF: 91

  HTML: 13

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• Intermediate care units in internal medicine: the case of Apulia

  Francesco Ventrella, Anna Belfiore, Antonio Greco, Franco Mastroianni, Salvatore Lenti, Domenico Ruggiero, Michele Cannone, Vincenzo Ostilio Palmieri, Massimo Errico

  https://doi.org/10.4081/itjm.2025.1960

  467

  PDF: 104

  HTML: 0

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• Peritoneal involvement in acute pericarditis with polyserositis may mimic acute cholecystitis: a case report

  Emanuele Bizzi, Francesco Moda, Massimo Pancrazi, Alice Pedroli, Ruggiero Mascolo, Antonio Luca Brucato

  https://doi.org/10.4081/itjm.2025.1931

  347

  PDF: 103

  HTML: 7

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• Gender differences and post-pandemic mental health impacts: a mediation study on Vietnamese adolescents

  Thanh Long Nguyen, Victor Storm, Lam Toi Phung, Cong Thien Le, Thi Thu Ha Le, Thi Hoa Nguyen, Son Tung Vu, Thien Thang Tran, Minh Hanh Vu, Van Tuan Nguyen

  https://doi.org/10.4081/itjm.2025.1888

  469

  PDF: 139

  SUPPLEMENTARY MATERIAL: 73

  HTML: 8

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• A “cold” case of myxedema coma

  Elisa Eletto, Carmine Siniscalchi, Nicoletta Cerundolo, Beatrice Prati, Lorenzo Finardi, Riccardo Simoni, Alberto Parise, Antonio Nouvenne, Tiziana Meschi

  https://doi.org/10.4081/itjm.2025.1999

  425

  PDF: 105

  HTML: 0

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• Impact of tumor necrosis factor-α and interleukin 6 polymorphisms on type 2 diabetes mellitus Sudanese patients

  Elmutuz H. Elssaig, Abdalla Eltoum Ali, Mohammed A. Alsubai, Tarig M.S. Alnour, Eltayib H. Ahmed-Abakur, Aadil Yousif, Bashayr Mudhhi Alshehri, Fatmah Ali Awaji, Arwa Murdi Alanazi, Fai Fahad Alanazi, Abdullah Ali Alghamdi

  https://doi.org/10.4081/itjm.2025.1967

  203

  PDF: 95

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• Pulmonary nodules in rheumatoid arthritis: the case of leflunomide

  Giovanni Simone Mancini, Silvia Rampini, Stefania Freguia, Clara Valsecchi, Domenico Cozzo, Anna Lou Christe, Adam Ogna

  https://doi.org/10.4081/itjm.2025.1964

  272

  PDF: 94

  HTML: 4

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• First-level clinical point-of-care ultrasound: an essential tool for today’s internist

  Mauro Silingardi, Nicola Mumoli, Emanuela Laurita, Elisa Romagnoli, Giovanna Casoli, Stefania Marengo, Federica Agrusta, Marinella Tricarico, Luisa Arnaldi, Giovanni Gardini, Francesco Dentali

  https://doi.org/10.4081/itjm.2025.1939

  480

  PDF: 62

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• Employing the European Thyroid Imaging Reporting and Data System 2017 classification in a malignancy risk stratification system for thyroid nodules at Can Tho Oncology Hospital from 2021 to 2023

  Vo Van Kha, Tran Thi Huong Ly, Pham Thi Thanh Hoa, Vo Huynh Nhu

  https://doi.org/10.4081/itjm.2025.1852

  759

  PDF: 92

  HTML: 10

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• Metformin’s therapeutic potential in adenomyosis: insights from interleukin 8 level

  Damas Hendriansyah, Nusratuddin Abdullah, Rudy B. Leonardy, Mardiah Tahir, Samrichard Rambulangi, Firdaus Hamid

  https://doi.org/10.4081/itjm.2025.1940

  733

  PDF: 71

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• An innovative model of university cooperation in developing countries: results of five years of experience in internal medicine, health promotion and education

  Filomena Pietrantonio, Vera Kopsaj, Francesco Rosiello, Aurora Tomassoni, Luca Moriconi, Donatella Padua

  https://doi.org/10.4081/itjm.2025.1941

  489

  PDF: 74

  HTML: 5

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• When should antihypertensive drug treatment be started? Discrepancies between the 2023 European Society of Hypertension and the 2024 European Society of Cardiology guidelines

  Giuseppe Mancia, Guido Grassi, Sverre E. Kjeldsen

  https://doi.org/10.4081/itjm.2025.1981

  782

  PDF: 92

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• Correlation between neutrophil-to-lymphocyte ratio and soluble FMS-like tyrosine kinase 1 in pregnant women with preeclampsia

  Kiki Rizki Amelia, Efendi Lukas, Nurbani Bangsawan, Isharyah Sunarno, Retno Budiarti Farid, Sriwijaya Qadar

  https://doi.org/10.4081/itjm.2025.1924

  349

  PDF: 83

  HTML: 7

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• Mentzer Index and Red Cell Distribution Width Index in differentiating iron deficiency anemia and β-thalassemia trait

  Rabab H. Elshaikh, Ashok Kumar Sah, Abdelrahman Mohamed Abukanna, Abdulrahman Algarni, Ammar Abdelmola, Hussam Ali Osman, Tagwa Yousif Elsayed Yousif, Elryah I. Ali, Hiba Ali, Ayman Hussein Alfeel

  https://doi.org/10.4081/itjm.2025.1892

  1219

  PDF: 165

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• Cytokine profile in COVID-19 infection: focus on interleukin-13, interleukin-33, and tumor necrosis factor-α as immunological markers

  Huda Saleem, Wafaa Hazim, Batool Mutar Mahdi, Mohammed S. Al-Iedani

  https://doi.org/10.4081/itjm.2025.1823

  411

  PDF: 302

  SUPPLEMENTARY MATERIAL: 176

  HTML: 82

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• The man from the stars: a narrative approach to neglected diseases

  Paolo Agostinis, Teresa Michelutti, Laura Iogna Prat, Omar Simonetti

  https://doi.org/10.4081/itjm.2025.1900

  258

  PDF: 241

  HTML: 76

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• The role of genetic variations in metabolic syndrome: insights into etiology, diagnosis, and management

  Darla Srinivasa Rao, Ajay Kumar, Shagun Agarwal, Rabab Hassan Elshaikh, AjabSingh Choudhary, Ranjay Kumar Choudhary, Assad M A Babker, Rohit Rathore, Zhannat Nurmakhanova, Zhanar Nurgaliyeva, Abdugani Musayev, Ashok Kumar Sah

  https://doi.org/10.4081/itjm.2025.1908

  812

  PDF: 434

  HTML: 79

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• Embracing artificial intelligence in internal medicine: a tool for physicians and patients

  Matteo Giorgi-Pierfranceschi

  https://doi.org/10.4081/itjm.2025.1791

  430

  PDF: 246

  HTML: 4

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• Immunohistochemical expression of transient receptor potential vanilloid 1 in World Health Organization grade IV astrocytoma, oral squamous cell carcinoma and bladder carcinoma

  Imrana Tanvir, Samina Qamar, Ahmad Alwazzan, Khurram Mehboob, Yousef Almehmadi, Ebtihal Ali Alharbi, Shadi Ahmed Alahmadi, Hafsa Adnan

  https://doi.org/10.4081/itjm.2025.1893

  355

  PDF: 334

  HTML: 78

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• Effect of magnesium and potassium on rheumatoid arthritis factor and quality of life in patients with type 2 diabetes mellitus: a randomized control trial

  Hafiza Sonia Bibi, Uzma Rafi, Sidra Khalid, Riffat Mehboob, Anbreen Bibi, Hani Sadaka Shalabi, Mohammed A. Zaher, Samy A. Abusikkien

  https://doi.org/10.4081/itjm.2025.1874

  587

  PDF: 316

  HTML: 74

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• La sindrome cardio-nefro-metabolica

  Andrea Montagnani, Dario Manfellotto

  1-38

  https://doi.org/10.4081/itjm.q.2025.1

  474

  PDF: 491

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• Diagnostic and therapeutic care pathway of the Cardiac Network for Heart Failure

  Pasquale Palmiero, Matteo Durante, Maria Maiello, Valentina D’Andria, Cosima Caputo, Lucia Giordano

  https://doi.org/10.4081/itjm.2025.1927

  545

  PDF: 293

  HTML: 87

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• A toothpick man user with COVID-19

  Francesco Serafini, Elia Vettore, Fabio Presotto

  https://doi.org/10.4081/itjm.2025.1897

  345

  PDF: 236

  HTML: 71

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• Visceral leishmaniasis and lymphoma: a rare and dangerous couple

  Nicola Battino, Antonio Pisano

  https://doi.org/10.4081/itjm.2025.1843

  334

  PDF: 260

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• CO-St (COVID 19-study): sex differences in the treatment of COVID-19

  Manuel Monti, Tiziana Ciarambino, Filomena Pietrantonio, Sara Rotunno, Alessandra Fiorentini, Rosalba Cipriani, Giuseppe Campagna, Giuseppe Straface, Eleonora Pistella, Mauro Giordano, Orazio Valerio Giannico, Roberto Marchetti, Federica Lorenzi, Francesco Rosiello

  https://doi.org/10.4081/itjm.2025.1916

  452

  PDF: 298

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• Evaluation of the renal function among sickle cell patients: a cross-sectional study

  Talal Qadah, Anwar Refaei

  https://doi.org/10.4081/itjm.2025.1868

  339

  PDF: 318

  SUPPLEMENTARY MATERIAL: 155

  HTML: 68

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• Virus-induced asthma exacerbations in Vietnamese preschoolers

  Nguyen Thuy Van Thao, Tran Anh Tuan, Pham Hung Van, Le Thuong Vu

  https://doi.org/10.4081/itjm.2025.1818

  307

  PDF: 303

  HTML: 6

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• Acute kidney failure due to varicella-zoster virus solved by early antiviral treatment based on brivudin

  Fulvia Paolozzi, Pierpaolo Di Micco, Antonella Giliberti, Gianluca Latte, Maria Teresa Feola, Immacolata Gaia Paduano, Concetta Schiano, Maurizio Latte

  https://doi.org/10.4081/itjm.2025.1786

  436

  PDF: 327

  HTML: 76

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• Serum transferrin level in type-2 diabetic patients in association with sociodemographic profile and dietary habits

  Anza Khan, Uzma Rafi, Riffat Mehboob, Sajid Hameed, Uzma Malik, Zainab Zubair, Imran Shahid

  https://doi.org/10.4081/itjm.2025.1873

  408

  PDF: 331

  HTML: 76

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• An algorithm for the management of chronic obstructive pulmonary disease patients in units of internal medicine

  Ombretta Para, Carmen Stabile, Donato Cinquepalmi, Maria Sandra Magnoni, Francesco Nasso, Flavio Tangianu, Mauro Silingardi, Antonella Valerio, Dario Manfellotto, Francesco Dentali

  https://doi.org/10.4081/itjm.2025.1838

  935

  PDF: 1359

  HTML: 85

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• The unseen connection: laryngeal carcinoma and thrombosis of the internal jugular vein

  Laura Leci-Tahiri, Lisa Tahiri, Valbona Zhjeqi, Emina Ramku

  https://doi.org/10.4081/itjm.2025.1882

  1724

  PDF: 274

  HTML: 99

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• The incidence of bleeding in patients with nonvalvular atrial fibrillation using anticoagulants: a real-world report with the biggest Vietnamese data

  Bui The Dung, Cao Ngoc Mai Han, Tran Hoa, Nguyen Thanh Hien

  https://doi.org/10.4081/itjm.2025.1807

  1878

  PDF: 347

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• Predictive value of Frank’s sign for obstructive coronary artery disease confirmed by coronary computed tomography angiography

  Truong Phi Hung, Nguyen Minh Kha, Dang Tuong Vi, Tran Trong Nhan, Hoang Van Sy

  https://doi.org/10.4081/itjm.2025.1863

  2203

  PDF: 417

  SUPPLEMENTARY MATERIAL: 189

  HTML: 109

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• First evidence of immunomodulation of the renin-angiotensin system through substance P/neurokinin 1 receptor: a case and control study in hypertension and cardiac patients

  Ibrahim M. Alanazi, Riffat Mehboob, Ayesha Tariq, Sajid Hameed, Uzma Malik, Noreen Sarwar, Imran Shahid, Khurram Mehboob

  https://doi.org/10.4081/itjm.2025.1870

  1178

  PDF: 592

  HTML: 72

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• Right ventricular failure due to subacute massive pulmonary embolism

  Claudio Giumelli, Giacomo Bussolati, Patricia Granauro, Paolo Montanari

  https://doi.org/10.4081/itjm.2025.1747

  1453

  PDF: 309

  VIDEO 1: 172

  HTML: 76

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