Case Reports
Vol. 19 No. 4 (2025)
https://doi.org/10.4081/itjm.2025.1869

What does a fall to the ground hide? An atypical onset of follicular B-cell lymphoma

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Published: 15 October 2025
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Follicular B-cell lymphoma, meningeal involvement, atypical clinical onset

Authors

Maurizio Renda
maurizio.renda@hsrgiglio.it
https://orcid.org/0009-0009-0474-7279
Internal Medicine Unit, Fondazione Istituto G. Giglio, Cefalù, Italy.
Silvia Scriffignano
https://orcid.org/0000-0001-5774-9643
Internal Medicine Unit, Fondazione Istituto G. Giglio, Cefalù, Italy.
Sabrina Mancuso
https://orcid.org/0009-0001-3015-3847
Internal Medicine Unit, Fondazione Istituto G. Giglio, Cefalù, Italy.
Silvana Leanza
https://orcid.org/0000-0001-8672-7486
General Surgery Unit, Fondazione Istituto G. Giglio, Cefalù, Italy.
Maurizio Musso
Oncohematology Unit, Casa di Cura “La Maddalena”, Palermo, Italy.
Valerio Alaimo
Radiology and Diagnostic Imaging Unit, Fondazione Istituto G. Giglio, Cefalù, Italy.

Follicular B-cell lymphoma is an indolent B-cell non-Hodgkin lymphoma, typically associated with favorable long-term outcomes and extended survival when diagnosed early. This lymphoma predominantly presents with lymphadenopathy and bone marrow involvement, while central nervous system infiltration remains exceptionally rare, and it has been reported in a few cases. Here, we present a peculiar case of follicular B-cell lymphoma with an unusual neurological onset due to meningeal involvement. Moreover, we studied the histologic expression of the disease in the three different anatomical sites involved: lymph nodes, bone marrow, and dura mater. Due to the paucity of literature data on this topic, we believe that this clinical case should be worthy of attention to help physicians when dealing with differential diagnosis in patients with neurological symptoms.

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What does a fall to the ground hide? An atypical onset of follicular B-cell lymphoma. (2025). Italian Journal of Medicine, 19(4). https://doi.org/10.4081/itjm.2025.1869
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