Case Reports
15 October 2025
Early Access
https://doi.org/10.4081/itjm.2025.1869

What does a fall to the ground hide? An atypical onset of follicular B-cell lymphoma

Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Follicular B-cell lymphoma, meningeal involvement, atypical clinical onset
27
Views
18
Downloads

Authors

Maurizio Renda
maurizio.renda@hsrgiglio.it
https://orcid.org/0009-0009-0474-7279
Internal Medicine Unit, Fondazione Istituto G. Giglio, Cefalù, Italy.
Silvia Scriffignano
https://orcid.org/0000-0001-5774-9643
Internal Medicine Unit, Fondazione Istituto G. Giglio, Cefalù, Italy.
Sabrina Mancuso
https://orcid.org/0009-0001-3015-3847
Internal Medicine Unit, Fondazione Istituto G. Giglio, Cefalù, Italy.
Silvana Leanza
https://orcid.org/0000-0001-8672-7486
General Surgery Unit, Fondazione Istituto G. Giglio, Cefalù, Italy.
Maurizio Musso
Oncohematology Unit, Casa di Cura “La Maddalena”, Palermo, Italy.
Valerio Alaimo
Radiology and Diagnostic Imaging Unit, Fondazione Istituto G. Giglio, Cefalù, Italy.

Follicular B-cell lymphoma is an indolent B-cell non-Hodgkin lymphoma, typically associated with favorable long-term outcomes and extended survival when diagnosed early. This lymphoma predominantly presents with lymphadenopathy and bone marrow involvement, while central nervous system infiltration remains exceptionally rare, and it has been reported in a few cases. Here, we present a peculiar case of follicular B-cell lymphoma with an unusual neurological onset due to meningeal involvement. Moreover, we studied the histologic expression of the disease in the three different anatomical sites involved: lymph nodes, bone marrow, and dura mater. Due to the paucity of literature data on this topic, we believe that this clinical case should be worthy of attention to help physicians when dealing with differential diagnosis in patients with neurological symptoms.

Altmetrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC
Alaggio R, Amador C, Anagnostopoulos I, et al. The 5th edition of the World Health Organization classification of haematolymphoid tumours: lymphoid neoplasms. Leukemia 2022;36:1720-48. DOI: https://doi.org/10.1038/s41375-022-01620-2
Campo E, Jaffe ES, Cook JR, et al. the international consensus classification of mature lymphoid neoplasms: a report from the Clinical Advisory Committee. Blood 2022;140:1229-53. DOI: https://doi.org/10.1182/blood.2022015851
Jacobsen E. Follicular lymphoma: 2023 update on diagnosis and management. Am J Hematol 2022;97:1638-51. DOI: https://doi.org/10.1002/ajh.26737
Carbone A, Roulland S, Gloghini A, et al. Follicular lymphoma. Nat Rev Dis Primers 2019;5:83. DOI: https://doi.org/10.1038/s41572-019-0132-x
Tsuboi Y, Shimizu M, Kuroda A, et al. Follicular lymphoma with secondary central nervous system relapse: a case report and literature review. Oxf Med Case Reports 2023;2023:omad118. DOI: https://doi.org/10.1093/omcr/omad118
Schaff LR, Grommes C. Primary central nervous system lymphoma. Blood 2022;140:971-9. DOI: https://doi.org/10.1182/blood.2020008377
Karschnia P, Batchelor TT, Jordan JT, et al. Primary dural lymphomas: clinical presentation, management, and outcome. Cancer 2020;126:2811-20. DOI: https://doi.org/10.1002/cncr.32834
Spectre G, Gural A, Amir G, et al. Central nervous system involvement in indolent lymphomas. Ann Oncol 2005;16:450-4. DOI: https://doi.org/10.1093/annonc/mdi076
Hollender A, Kvaloy S, Nome O, et al. Central nervous system involvement following diagnosis of non-Hodgkin's lymphoma: a risk model. Ann Oncol 2002;13:1099-107. DOI: https://doi.org/10.1093/annonc/mdf175

How to Cite



What does a fall to the ground hide? An atypical onset of follicular B-cell lymphoma. (2025). Italian Journal of Medicine. https://doi.org/10.4081/itjm.2025.1869
Copyright (c) 2025 the Author(s) Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.