Correlation of serum cardiolipin levels with physical activity in type 2 diabetes mellitus patients

Cardiolipin, a critical phospholipid involved in mitochondrial function, has a potential role in the pathogenesis of type 2 diabetes mellitus. This research aims to assess serum cardiolipin levels in type 2 diabetic patients and examine their correlation with their physical activity, age, and gender. The study employed cross-sectional research conducted at Lahore Garrison University and Lahore Medical Research Center. Physical activity and serum cardiolipin levels were measured using the International Physical Activity Questionnaire (IPAQ) and a chemical analyzer, respectively. A sample size of 80 participants was analyzed statistically using t-tests and analysis of variance in GraphPad Prism 8.0.2 (263). IPAQ demonstrated that most patients (56%) were of the moderate activity category. Across age groups, there were significant differences in cardiolipin and blood sugar levels. Similarly, important differences were found in serum cardiolipin (p=0.0001), glycated hemoglobin (p=0.0499), and blood sugar (p=0.0021) levels among low, moderate, and vigorous physical activity groups. No significant difference was noticed among genders. Conclusions: Our research highlighted the potential age-dependent impact of physical activity on cardiolipin levels, emphasizing its relevance to mitochondrial health. A significant difference was also found between physical activity and blood sugar.