Case Reports
Vol. 19 No. 2 (2025)
A case report of bladder cancer-related acquired hemophilia A
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Published: 17 June 2025
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Acquired hemophilia A is an extremely rare (incidence of 1.5/1,000,000) and potentially life-threatening disorder characterized by the production of autoantibodies against coagulation factor VIII with a consequent increased bleeding risk; it mainly affects elderly people, and approximately 6-22% of the cases are cancer-related. We report the case of an 84-year-old man who presented with subcutaneous hematomas and anemia; he had prolonged activated partial thromboplastin time, coagulation factor VIII deficiency, and high levels of factor VIII antibodies, and he was successfully treated with prednisone, cyclophosphamide, and recombinant activated factor VII as a bypassing agent.
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Citations
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How to Cite
A case report of bladder cancer-related acquired hemophilia A. (2025). Italian Journal of Medicine, 19(2). https://doi.org/10.4081/itjm.2025.2019
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