Original Articles
13 May 2025
Early Access
Impact of tumor necrosis factor-α and interleukin 6 polymorphisms on type 2 diabetes mellitus Sudanese patients
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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Extensive studies in humans over the last decades have shown the significant functions of cytokines in diabetes development. The present study aimed to assess the impact of tumor necrosis factor (TNF)-α and interleukin (IL) 6 polymorphisms on type 2 diabetes mellitus (T2DM). The study involved 450 participants; 200 individuals were included in the control group, and 250 individuals represented T2DM patients. The polymerase chain reaction-restriction fragment length polymorphism technique was used to identify the genotypes and alleles of the TNF-α 308G/A variants rs1800629 and IL-6 (-174 C→G) variants rs1800629, while amplification refractory mutation system polymerase chain reaction is used to identify genetic variations of IL-6 (-174 C→G). The result revealed a statistically significant (p=0.0028) difference in the frequency of the AA genotype of the TNF-α rs1800629 variant between the study group and the control group. Interestingly, the findings also showed a significant difference (p=0.0001) in the frequency of the CC genotype of the IL-6-rs1800795 variant between the study and control groups. The TNF-α gene (308G/A) and the IL-6 (-174 C→G) polymorphism were found to be strongly related to an elevated risk of T2DM in the Sudanese population.
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Impact of tumor necrosis factor-α and interleukin 6 polymorphisms on type 2 diabetes mellitus Sudanese patients. (2025). Italian Journal of Medicine. https://doi.org/10.4081/itjm.2025.1967
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