Original Articles
Vol. 19 No. 4 (2025)
https://doi.org/10.4081/itjm.2025.2015

Relationship of adiponectin levels with the severity of chronic obstructive pulmonary disease

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Received: 15 April 2025
Accepted: 4 May 2025
Published: 22 December 2025
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COPD, adiponectin, adipokines

Authors

Rismawaty Samonding
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Hasanuddin University, Wahidin Sudirohusodo Hospital, Makassar, Indonesia.
Muh Ilyas
Specialist Doctoral Education Program-1, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Hasanuddin University, Wahidin Sudirohusodo Hospital, Makassar, Indonesia.
Bulkis Natsir
Specialist Doctoral Education Program-1, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Hasanuddin University, Wahidin Sudirohusodo Hospital, Makassar, Indonesia.
Irawaty Djaharuddin
irawatydjaharuddin@unhas.ac.id
Specialist Doctoral Education Program-1, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Hasanuddin University, Wahidin Sudirohusodo Hospital, Makassar, Indonesia.
Sitti Nurisyah
Specialist Doctoral Education Program-1, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Hasanuddin University, Wahidin Sudirohusodo Hospital, Makassar, Indonesia.
Erwin Arief
Specialist Doctoral Education Program-1, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Hasanuddin University, Wahidin Sudirohusodo Hospital, Makassar, Indonesia.

Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and tissue damage. Adipose tissue has been identified as a contributing factor to systemic inflammation in COPD. Adiponectin is present in the airway epithelial cells and bronchoalveolar lavage fluid of patients with COPD. This suggests that adiponectin and COPD patients are related. This study aims to determine the relationship between adiponectin levels and the severity of COPD. Patients with COPD who are registered at Hasanuddin University Hospital and who fit the study’s criteria served as the subjects of this cross-sectional study. The patients who had other chronic conditions were excluded. Every patient had their adiponectin levels measured. Based on the ABE group, the severity of COPD was evaluated. Version 29.0 of SPSS was used. A total of 88 subjects were included, with 12 (13.6%) women and 76 (86.4%) men. The mean age was 64.29±9.50 years. The mean adiponectin level was 33.57±14.61. Adiponectin levels were significantly correlated with the severity of COPD (p=0.001). In conclusion, the severity of COPD decreases with increasing adiponectin levels.

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How to Cite



Relationship of adiponectin levels with the severity of chronic obstructive pulmonary disease. (2025). Italian Journal of Medicine, 19(4). https://doi.org/10.4081/itjm.2025.2015
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