Original Articles
11 October 2024
Vol. 18 No. 3 (2024)
https://doi.org/10.4081/itjm.2024.1800

Comparative analysis of advanced polymerase chain reaction-based detection of Parvovirus B19 in first-trimester pregnant women at Thumbay Hospital, Ajman, United Arab Emirates

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Parvovirus B19, anti-spiking salivary, vaccine IgA antibodies, PCR, pregnant women
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Authors

Alaa M. Abdalhadi
alaa-m89@hotmail.com
Medical Laboratory Sciences Program, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates.
Asaad Babker
https://orcid.org/0000-0002-5022-5676
Medical Laboratory Sciences Program, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates.
Ahmed Luay Osman
Medical Laboratory Sciences Program, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates.
Israa M. Abdalhadi
Medical Laboratory Sciences Program, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates.
Mona A. Alblooshi
Medical Laboratory Sciences Program, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates.
Fawzia A. AlObeidli
Medical Laboratory Sciences Program, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates.
Israa O. Yousif
Medical Laboratory Sciences Program, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates.
Hassan Higazi
Medical Laboratory Sciences Program, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates.

Human parvovirus B19 (B19V) is considered a prevalent single-stranded DNA virus belonging to the Parvoviridae family. It can be vertically transmitted from mother to fetus and is primarily spread by respiratory droplets. The clinical presentation of B19V infection varies based on the viral strain and the individual’s age and immune status. This study aims to determine the prevalence of B19V infection among pregnant women in the first trimester and investigate the association between the virus and infected pregnancy results. A descriptive cross-sectional study was conducted at Thumbay Hospital, Ajman, United Arab Emirates. Pregnant women in their first trimester who sought antenatal care were included in the study. The enzyme-linked immunosorbent assay was used, and the results were confirmed with polymerase chain reaction (PCR). All data were analyzed using SPSS statistical methods. The study population consisted of pregnant women in the first trimester attending Thumbay Hospital. The study focused on B19V prevalence among 87 pregnant women in the first trimester and its association with risk factors. Results showed almost 9% overall prevalence of B19V infection, with higher rates among younger women and women with previous pregnancies. The B19V PCR detects only 5 counts, with 5.7% of samples infected with B19V associated with a higher risk of fetal loss. Early gestational age was detected to have a significant association with a p-value of 0.006. There was an insignificant association between B19V immunoglobulin M PCR infection and others (gravidity along with history of miscarriage and history of blood transfusion). This study provided valuable insights into the prevalence and risk factors associated with B19V infection among pregnant women in the first trimester. The findings highlighted the importance of early detection and appropriate management of B19V infection to prevent severe complications and improve pregnancy outcomes.

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Pénzes JJ, De Jong EP, Örvell C, et al. Primate erythroparvovirus 1, the aetiological agent of erythema infectiosum, is widespread in Dutch children and their parents. J Clin Virol 2020;130:104576.
Ganaie SS, Qiu J. Recent advances in replication and infection of human parvovirus B19. Front Cell Infect Microbiol 2018;8:166. DOI: https://doi.org/10.3389/fcimb.2018.00166
Lipsitch M, Kahn R, Mina MJ. Antibody testing will enhance the power and accuracy of COVID-19-prevention trials. Nat Med 2020;26:818-9. DOI: https://doi.org/10.1038/s41591-020-0887-3
Servant-Delmas A, Morinet F. Update of the Human Parvovirus B19 Biology. Transfusion Clinique et Biologique 2016;23:5-12. DOI: https://doi.org/10.1016/j.tracli.2015.11.006
Heegaard ED, Brown KE. Human parvovirus B19. Clin Microbiol Rev 2002;15:485-505. DOI: https://doi.org/10.1128/CMR.15.3.485-505.2002
Erdman DD, Anderson LJ, Adams DR, et al. Human parvovirus B19. In: Versalovic J, Carroll KC, Funke G, et al., eds. Manual of clinical microbiology. 11th ed. Washington DC, USA: ASM Press; 2018. pp 1911-24.
Luo Y, Lou S, Deng X, et al. Parvovirus B19 infection of human primary erythroid progenitor cells triggers ATR-Chk1 signaling, which promotes B19 virus replication. J Virol 2011;85:8046-55. DOI: https://doi.org/10.1128/JVI.00831-11
Lamont RF, Sobel JD, Vaisbuch E, et al. Parvovirus B19 infection in human pregnancy. BJOG 2011;118:175-86. DOI: https://doi.org/10.1111/j.1471-0528.2010.02749.x
Schenk T, Enders M, Pollak S, al. High prevalence of human parvovirus B19 DNA in myocardial autopsy samples from subjects without myocarditis or dilated cardiomyopathy. J Clin Microbiol 2009;47:106-10. DOI: https://doi.org/10.1128/JCM.01672-08
Bonvicini F, Bua G, Gallinella G. Parvovirus B19 infection in pregnancy-awareness and opportunities. Curr Opin Virol 2017;27:8-14. DOI: https://doi.org/10.1016/j.coviro.2017.10.003
Bascietto F, Liberati M, Murgano D, et al. Outcome of fetuses with congenital parvovirus B19 infection: systematic review and meta-analysis. Ultrasound Obstet Gynecol 2018;52:569-76. DOI: https://doi.org/10.1002/uog.19092
Kielaite D, Paliulyte V. Parvovirus (B19) infection during pregnancy: possible effect on the course of pregnancy and rare fetal outcomes. a case report and literature review. Medicina 2022;58:664. DOI: https://doi.org/10.3390/medicina58050664
Alexander V, Das S, Mangan AS, Iyadurai R. Acute parvovirus B19 infection presenting as rheumatoid arthritis mimic. J Family Med Prim Care 2019;8:1257-9. DOI: https://doi.org/10.4103/jfmpc.jfmpc_25_19
Crane J, Mundle W, Boucoiran I, et al. Parvovirus B19 infection in pregnancy. JOGC 2014;36:1107-16. DOI: https://doi.org/10.1016/S1701-2163(15)30390-X
Ergaz Z, Ornoy A. Parvovirus B19 in pregnancy. Reprod Toxicol 2006;21:421-35. DOI: https://doi.org/10.1016/j.reprotox.2005.01.006
Hussein MM, Hasan ASH, Kadem JI. Parvovirus B19 infection and seroprevalence among patients with thalassemia in Diyala province, Iraq. Ann Tropical Med Public Health 2021;24. DOI: https://doi.org/10.36295/ASRO.2021.24207
Elnifro EM, Nisha AK, Alambsoot M, et al. Seroprevalence of parvovirus B19 among pregnant women in Tripoli, Libya. J Infect Dev Crties 2009;30:218-20. DOI: https://doi.org/10.3855/jidc.38
Mohammed S, Yawoz Noraldeen M. Investigation of human parvovirus B19 seroprevalence among pregnant women experiencing spontaneous abortion in Kirkuk City, Iraq. NTU-JPS 2023;2:27-34. DOI: https://doi.org/10.56286/ntujps.v2i4.591
Adam O, Makkawi T, Reber U, et al. The seroprevalence of parvovirus B19 infection in pregnant women in Sudan. Epidemiol Infect 2015;143:242-8. DOI: https://doi.org/10.1017/S0950268814000600
Jamjoom GA, Azhar EI, Kao MA, Radadi RM. Seroepidemiology of asymptomatic dengue virus infection in Jeddah, Saudi Arabia. Virology 2016;7:1-7. DOI: https://doi.org/10.4137/VRT.S34187
Arabzadeh SA, Alizadeh F, Tavakoli A, et al. Human parvovirus B19 in patients with beta thalassemia major from Tehran, Iran. Blood Res 2017;52:50-4. DOI: https://doi.org/10.5045/br.2017.52.1.50
Skjoldebrand-Sparre L, Tolfvenstam T, Papadogiannais N, et al. Parvovirus B19 infection: association with third-trimester intrauterine fetal death. BJOG 2000;107:476-80. DOI: https://doi.org/10.1111/j.1471-0528.2000.tb13265.x
Gielchinsky Y, Rojansky N, Fasouliotis SJ, Ezra Y. Placenta accreta--summary of 10 years: a survey of 310 cases. Placenta 2002;23:210-4. DOI: https://doi.org/10.1053/plac.2001.0764
Emiasegen SE, et al. Prevalence of parvovirus B19 infection in sickle cell anaemia patients in Nigeria. Virol J 2011;8:289.

How to Cite



Comparative analysis of advanced polymerase chain reaction-based detection of Parvovirus B19 in first-trimester pregnant women at Thumbay Hospital, Ajman, United Arab Emirates. (2024). Italian Journal of Medicine, 18(3). https://doi.org/10.4081/itjm.2024.1800
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