Original Articles
18 July 2023
Vol. 17 No. 2 (2023)
https://doi.org/10.4081/itjm.2023.1627

Association of TNF-α, IFN-γ, IL-6, and IL-10 with different clinical manifestations of hepatitis B infection

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TNF-α, IFN-γ, IL-6, IL-10, HBV
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Authors

Mudathir Abdelshafea Abdelkareem Abakar
Department of Microbiology and Immunology, Faculty of Medical Laboratory Sciences, Alzaiem Alazhari University, Khartoum North, Khartoum, Sudan.
Ashwag Ali Hussein Ali
Department of Microbiology and Immunology, Faculty of Medical Laboratory Sciences, Alzaiem Alazhari University, Khartoum North, Khartoum, Sudan.
Eman Damra Ahmed Elhassan
Department of Microbiology and Immunology, Faculty of Medical Laboratory Sciences, Alzaiem Alazhari University, Khartoum North, Khartoum, Sudan.
Esra Ali Hamuda Altaher
Department of Microbiology and Immunology, Faculty of Medical Laboratory Sciences, Alzaiem Alazhari University, Khartoum North, Khartoum, Sudan.
Nosaiba Hussein Abdalbasit Musa
Department of Microbiology and Immunology, Faculty of Medical Laboratory Sciences, Alzaiem Alazhari University, Khartoum North, Khartoum, Sudan.
Shamsoun Khamis Kafi
Department of Microbiology, Faculty of Medical Laboratory Sciences-National Ribat University, Khartoum, Sudan.
Amira Eltom Fawzi Osman
Department of Microbiology and Immunology, Faculty of Medical Laboratory Sciences, Alzaiem Alazhari University, Khartoum North, Khartoum, Sudan.
Hisham Ali Waggiallah
hishamwagg30@hotmail.com
https://orcid.org/0000-0001-6591-1831
Department of Medical Laboratory Science, College of Applied Medical Science, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia.

Cytokines have a crucial part in the pathogenesis, persistence of infection, and prognosis of hepatitis B virus (HBV) infection as HBV does not cause direct liver destruction; rather, disease-related complications and prognosis are more associated with immune system action, specifically cytokines such as TNF-α, IFN-γ, IL-6, IL-10, and other cytokines. This study sought to link TNF-, IFN-, IL-6, and IL-10 to various clinical manifestations of HBV infection. Ninety sera were taken from HBV-infected patients, 30 (33.3%) of whom had liver cirrhosis, 30 (33.3%) were HBV carriers, 19 (21.2%) were acute HBV patients, and 11 (12.2%) were recently HBV infected. ELISA was used to determine the serum levels of TNF-α, IFN-γ, IL-6, and IL-10. HBV-infected patients with liver cirrhosis had considerably higher mean serum levels of IFN-γ (P=0.005) and IL-10 (P=0.003), but TNF-α and IL-6 were significantly higher in recent HBV-infected patients (P values 0.034 and 0.004, respectively). There were substantial changes in mean serum levels of TNF-α, IFN-γ, IL-6, and IL-10 at different phases of HBV infection, implying a role for cytokines in HBV etiology, chronicity, and consequences.

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How to Cite



Association of TNF-α, IFN-γ, IL-6, and IL-10 with different clinical manifestations of hepatitis B infection. (2023). Italian Journal of Medicine, 17(2). https://doi.org/10.4081/itjm.2023.1627
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