Age- and dose-independent adverse effect of venlafaxine-extended release on blood pressure: a case series of 13 normotensive psychiatric outpatients
Abstract
Dear Editor, the first antidepressant medication of the serotonin-norepinephrine reuptake inhibitor class is venlafaxine (effexor), which is taken orally with a half-life of 5 hours; however, its effective and chief metabolite (i.e., O-desmethylvenlafaxine) owns a half-life of 11 hours. [...]
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References
- Montastruc JL, Rousseau V, de Canecaude C, et al. Role of serotonin and norepinephrine transporters in antidepressant-induced arterial hypertension: a pharmacoepidemiological-pharmacodynamic study. Eur J Clin Pharmacol 2020;76:1321-7. DOI: https://doi.org/10.1007/s00228-020-02913-0
- O’Donnell JM, Bies RR, Williams AJ. Drug therapy of depression and anxiety disorders. In: Brunton LL, Knollman BC. (eds). Goodman & Gilman’s: The Pharmacological Basis of Therapeutics, 14th ed. McGraw-Hill Education, New York; 2023.
- Wathra R, Mulsant BH, Thomson L, et al. Hypertension and orthostatic hypotension with venlafaxine treatment in depressed older adults. J Psychopharmacol 2020;34:1112-8. DOI: https://doi.org/10.1177/0269881120944154
- Kıvrak Y, Güvenç TS, Akbulut N, et al. Accelerated hypertension after venlafaxine usage. Case Rep Psychiatry 2014:2014:659715. DOI: https://doi.org/10.1155/2014/659715
- Humbert X, Fedrizzi S, Chrétien B, et al. Hypertension induced by serotonin reuptake inhibitors: analysis of two pharmacovigilance databases. Fundam Clin Pharmacol 2019;33:296-302. DOI: https://doi.org/10.1111/fcp.12440
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