Case Reports
29 November 2023
Vol. 17 No. 3 (2023)
Lung damages of malaria: a differential diagnosis and treatment in emergency room of a rare case
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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Pulmonary involvement occurs in 3 to 10% of the cases of Plasmodium falciparum malaria and represents the most severe complication of this infection, with a lethality of about 70%. The antigens released by the parasite play an important role in the induction and worsening of lung damage. Capillary endothelial cells, which control the flux of fluids to the interstitial space, appear to be the most complicated structures. The clinical manifestations of pulmonary involvement may start suddenly at any time during the course of malaria, even after the disappearance of the circulating parasite. Hyperparasitemia predisposes to these factors. Treatment with corticosteroids is optional, and that is not often a benefit.
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www.Ecdc.annualreport 2021/malaria
ECDC SURVEILLANCE REPORT. Annual Epidemiological Report for 2017. Malaria. 2019. Available from: https://ecdc.europa.eu/sites/portal/files/documents/AER_for_2
Carannante N, Rossi M, Fraganza F, et al. A high PCT level correlates with disease severity in Plasmodium falciparum malaria in children. New Microbiologica 2017;40:72-4.
Marsh K, Forster D, Waruiru C, et al. Indicators of lifethreatening malaria in African children. N Eng J Med 1995;332:1399-404. DOI: https://doi.org/10.1056/NEJM199505253322102
World Health Organization pocket book of hospital care for children: guidelines for the management of common childhood illnesses 2nd ed.
Boccolini D, Menegon M, Di Luca M, et al. Non-imported malaria in Italy: paradigmatic approaches and public health implications following an unusual cluster of cases in 2017. BMC Public Health 2020;20:857. DOI: https://doi.org/10.1186/s12889-020-08748-9
Graham H, Bakare AA, Ayede AI, et al. Diagnosis of pneumonia and malaria in Nigerian hospitals: A prospective cohort study. Pediatr Pulmonol 2020;55:S37-S50.
Aitken EH, Negri EM, Barboza R, et al. Ultrastructure of the lung in a murine model of malaria-associated acute lung injury/acute respiratory distress syndrome. Malar J 2014;13:230. DOI: https://doi.org/10.1186/1475-2875-13-230
Guerrant RL, Walker DH, Weller PF. Tropical infectious diseases: Principles, patogens and practice. 6th Edition, Elsevier Churchill-Livingstone, Philadelphia, 2006;159.
Hiekkanen T, Skogberg K, Pettilä V. Evolution of plasma proinflammatory cytokines in malaria-related ARDS treated with corticosteroids. Intensive Care Med 2001;27:1823-4. DOI: https://doi.org/10.1007/s00134-001-1116-2
WHO Pocket book of hospital care for children, 2nd edition.
English M, Punt J, Mwangi I, et al. Clinical overlap between malaria and severe pneumonia in African children in hospital. Trans R Soc Trop Med Hyg 1996;90:658-62. DOI: https://doi.org/10.1016/S0035-9203(96)90423-X
Matthay MA, Zemans RL. The acute respiratory distress syndrome: pathogenesis and treatment. Annu Rev Pathol 2011;6:147-63. DOI: https://doi.org/10.1146/annurev-pathol-011110-130158
Van den Steen PE, Geurts N, Deroost K, et al. Immunopathology and dexamethasone therapy in a new model for malaria-associated acute respiratory distress syndrome. Am J Respir Crit Care Med 2010;181:957-68. DOI: https://doi.org/10.1164/rccm.200905-0786OC
Graham H, Bakare AA, Ayede AI, et al. Diagnosis of pneumonia and malaria in Nigerian hospitals: A prospective cohort study. Pediatr Pulmonol 2020;55:S37-S50. DOI: https://doi.org/10.1002/ppul.24691
Hussein MIH, Albashir AAD, Elawad OAMA, et al. Malaria and COVID-19: unmasking their ties. Malar J 2020;19:457. DOI: https://doi.org/10.1186/s12936-020-03541-w
Taylor WR, White NJ. Malaria and the lung. Clin Chest Med 2002;23:457-68. DOI: https://doi.org/10.1016/S0272-5231(02)00004-7
Van den Steen PE, Deroost K, Deckers J, et al. Pathogenesis of malaria-associated acute respiratory distress syndrome. Trends Parasitol. 2013;29:346-58. DOI: https://doi.org/10.1016/j.pt.2013.04.006
WHO. World malaria report 2019. Geneva: World Health Organization, 2019.
Laishram DD, Sutton PL, Nanda N, et al. The complexities of malaria disease manifestations with a focus on asymptomatic malaria. Malar J 2012;11:29. DOI: https://doi.org/10.1186/1475-2875-11-29
Karunaweera ND, Wijesekera SK, Wanasekera D, et al. The Paroxysm of Plasmodium Vivax Malaria. Trends Parasitol 2003;19:188-93. DOI: https://doi.org/10.1016/S1471-4922(03)00036-9
Nicholas M, Anstey SP, Cain JT, et al. Pulmonary manifestations of uncomplicated falciparum and vivax malaria: cough, small airways obstruction, impaired gas transfer, and increased pulmonary phagocytic activity. J Infect Dis 2002;185:1326-34. DOI: https://doi.org/10.1086/339885
Mohan A, Sharma SK, Bollineni S. Acute lung injury and acute respiratory distress syndrome in malaria. J Vector Borne Dis 2008;45:179-93.
O’Dempsey TJ, McArdle TF, Laurence BE, et al. Overlap in the clinical features of pneumonia and malaria in African children. Trans R Soc Trop Med Hyg 1993;87:662-5. DOI: https://doi.org/10.1016/0035-9203(93)90279-Y
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Lung damages of malaria: a differential diagnosis and treatment in emergency room of a rare case. (2023). Italian Journal of Medicine, 17(3). https://doi.org/10.4081/itjm.2023.1603
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