Evaluation of the pharmacoeconomics of drugs used for the treatment of long-term complications of sulfur mustard

  • Yunes Panahi Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran, Islamic Republic of.
  • Mostafa Ghanei Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran, Islamic Republic of.
  • Milad Vakili Zarch School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran, Islamic Republic of.
  • Zohreh Poursaleh Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran, Islamic Republic of.
  • Shahram Parvin Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran, Islamic Republic of.
  • Ramin Rezaee Department of Physiology and Pharmacology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran, Islamic Republic of.
  • Amirhossein Sahebkar | amir_saheb2000@yahoo.com Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran, Islamic Republic of.

Abstract

Sulfur Mustard (SM), a cytotoxic vesicant chemical warfare agent, has powerful irritant and blistering effects on the skin, eyes and respiratory tract. Since during the Iraq-Iran war, many Iranian soldiers and civilians were exposed to SM, there are several victims still suffering from long-term cutaneous, ocular and pulmonary complications. Currently, there is no definite treatment for long-term complications of SM, and only supportive medical care is being taken to minimize the symptoms. In this study, we compared the cost-effectiveness of common drugs that are used against long-term SM-induced complications in Iranian patients. In this review article, electronic databases were checked using the following key words: sulfur mustard, lung, skin, eye, cost-effectiveness, pharmacoeconomics and treatment. Abstracts of non-English papers and proceedings of congresses on SM were also assessed. Among the studied drugs, high-dose oral N-acetyl cysteine and long-acting inhaled corticosteroids against respiratory complications, topical corticosteroids and oral antihistamines against cutaneous complications and non-steroidal anti-inflammatory drugs and corticosteroids ophthalmic drops against ocular complications were found to be cost-effective. Usage of different drugs in the treatment of SM injuries in Iran, have imposed a significant economic burden to patients and their families because many drugs that are effective against chemical injuries are not covered by insurance. In addition, the development of more effective drugs in this field is considered as an urgent demand that should be noticed by the pharmaceutical industry.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.
Published
2016-08-29
Info
Issue
Section
Reviews
Keywords:
Sulfur mustard, lung, skin, eye, cost-effectiveness, treatment, pharmacoeconomics.
Statistics
  • Abstract views: 1549

  • PDF: 628
  • HTML: 499
How to Cite
Panahi, Y., Ghanei, M., Zarch, M. V., Poursaleh, Z., Parvin, S., Rezaee, R., & Sahebkar, A. (2016). Evaluation of the pharmacoeconomics of drugs used for the treatment of long-term complications of sulfur mustard. Italian Journal of Medicine, 11(2), 102-113. https://doi.org/10.4081/itjm.2016.743

Most read articles by the same author(s)