Reviews
Vol. 15 No. 3 (2021)
Meta-analysis of pharmacist-led and pharmacist-physician intervention on blood pressure control
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: 12 January 2021
Accepted: 9 February 2021
Accepted: 9 February 2021
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Effective intervention is a significant component in the improvement of blood pressure control and patient adherence. Blood pressure control includes different self-monitoring techniques, mobile health monitoring, or healthcare professionals' interventions. This study aims to compare, analyze, and interpret the effectiveness of pharmacist-physician collaboration and pharmacist- led interventions. Meta-analysis was performed using MEDLINE via PubMed, EMBASE, EBSCO, Web of Science, Scopus, and the Cochrane Library databases between 2008-2018. Of the 51 relevant systematic reviews identified, 15 were of sufficient quality and included in the data synthesis. The breakdown of the 15 included 7 (n=2026) pharmacist and 8 pharmacist-physician interventions (n=2361). The impact of pharmacist-physician collaboration and pharmacist-led interventions on Systolic Blood Pressure was -8.22 (-11.01; -5.42) (P<0.01) and -7.68 (-9.30; -6.06) (P=0.35), respectively. On the other hand, similar correlation for Diastolic Blood Pressure for the impact of pharmacist-physician collaboration and pharmacist-led interventions was -3.55 (-4.54; -2.55) (P=0.49) and -2.58 (-3.76; -1.39) (P=0.24), respectively. These results suggest that both interventions are effective for blood pressure control. However, when two meta-analyses were compared, it was found that pharmacist-physician collaboration was more effective than pharmacist-led interventions. This finding highlights the importance of multidisciplinary approaches during blood pressure control procedures. When a holistic view is considered; especially cost-effectiveness, future studies must be diversified to encompass a broader context and impact analysis.
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World Health Organization Report. A Global brief of hypertension, World Health Day 2013, WHO/DCO/WHD/2013.2 2013. Available from: https://ish-world.com/downloads/pdf/global_brief_hypertension.pdf. Accessed: 2013.
Robitaille C, Dai S, Waters C, et al. Diagnosed hypertension in Canada: incidence, prevalence and associated mortality. CMAJ 2012;184:49-56.
Kearney PM, Whelton M, Reynolds K, et al. Global burden of hypertension: analysis of worldwide data. Lancet 2005;365:217-23.
Berenson GS. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med 1998;338:1650-6.
Thompson DW, Furlan AJ. Clinical epidemiology of stroke. Neurol Clin 1996;14:309-15.
Ong KL, Cheung BM, Man YB, et al. Prevalence, awareness, treatment, and control of hypertension among United States adults 1999-2004. Hypertension 2007;49:69-75.
Go AS, Bauman MA, King SMC, et al. An effective approach to high blood pressure control: a science advisory from the American Heart Association, the American College of Cardiology, and the Centers for Disease Control and Prevention. J Am Coll Cardiol 2014;63:1230-8.
Borenstein JE, Graber G, Saltiel E, et al. Physician-pharmacist co-management of hypertension: a randomized, comparative trial. Pharmacotherapy 2003;23:209-16.
Hunt JS, Siemienczuk J, Pape G, et al. A randomized controlled trial of team-based care: impact of physician-pharmacist collaboration on uncontrolled hypertension. J Gen Intern Med 2008;23:1966-72.
Carter BL, Ardery G, Dawson JD, et al. Physician and pharmacist collaboration to improve blood pressure control. Arch Intern Med 2009;169:1996-2002.
Carter BL, Rogers M, Daly J, et al. The potency of team-based care interventions for hypertension: a meta-analysis. Arch Intern Med 2009;169:1748-55.
Magid DJ, Olson KL, Billups SJ, et al. A pharmacist-led, American Heart Association Heart360 Web-enabled home blood pressure monitoring program. Circ Cardiovasc Qual Outcomes 2013;6:157-63.
Mancia G, Facchetti R, Bombelli M, et al. Long-term risk of mortality associated with selective and combined elevation in office, home, and ambulatory blood pressure. Hypertension 2006;47:846-53.
Margolis KL, Asche SE, Bergdall AR, et al. Effect of home blood pressure telemonitoring and pharmacist management on blood pressure control: a cluster randomized clinical trial. JAMA 2013;310:46-56.
Green BB, Cook AJ, Ralston JD, et al. Effectiveness of home blood pressure monitoring, Web communication, and pharmacist care on hypertension control: a randomized controlled trial. JAMA 2008;299:2857-67.
Chisholm-Burns MA, Lee JK, Spivey CA, et al. US pharmacists’ effect as team members on patient care: systematic review and meta-analyses. Med Care 2010;923-33.
Frail CK, Cooper S, Gallagher T, et al. A technology-supported collaboration between a health plan and a community pharmacy to improve blood pressure control. J Am Pharm Assoc 2017;57:630-4.
Koshman SL, Charrois TL, Simpson SH, et al. Pharmacist care of patients with heart failure: a systematic review of randomized trials. Arch Intern Med 2008;168:687-94.
Namara KPM, Dunbar JA, Philpot B, et al. Potential of pharmacists to help reduce the burden of poorly managed cardiovascular risk. Aust J Rural Health 2012;20:67-73.
Fikri-Benbrahim N, Faus MJ, MartÃnez-MartÃnez F, Sabater-Hernández D. Impact of a community pharmacists’ hypertension-care service on medication adherence. The AFenPA study. Res Social Adm Pharm 2013;9:797-805.
Yarnall KS, Østbye T, Krause KM, et al. Peer reviewed: family physicians as team leaders: ‘time’ to share the care. Prev Chronic Dis 2009;6:59.
Santschi V, Chiolero A, Colosimo AL, et al. Improving blood pressure control through pharmacist interventions: a meta-analysis of randomized controlled trials. J Am Heart Assoc 2014;3:e000718.
Altowaijri A, Phillips CJ, Fitzsimmons D. A systematic review of the clinical and economic effectiveness of clinical pharmacist intervention in secondary prevention of cardiovascular disease. J Manage Care Pharm 2013;19:408-16.
Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg 2010;8:336-41.
Hutton B, Salanti G, Caldwell DM, et al. The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med 2015;162:777-84.
Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions. Chichester, West Sussex, UK; Hoboken NJ: Wiley-Blackwell; 2008.
Smith SM, Carris NW, Dietrich E, et al. Physician-pharmacist collaboration versus usual care for treatment-resistant hypertension. J Am Soc Hypertens 2016;10:307-17.
Carter BL, Bergus GR, Dawson JD, et al. A cluster randomized trial to evaluate physician/pharmacist collaboration to improve blood pressure control. J Clin Hypertens 2008;10:260-71.
Polgreen LA, Han J, Carter BL, et al. Cost-effectiveness of a physician–pharmacist collaboration intervention to improve blood pressure control. Hypertension 2015;66:1145-51.
Hirsch JD, Steers N, Adler DS, et al. A randomized pragmatic trial of primary care based pharmacist-physician collaborative medication therapy management for hypertension. Clin Ther 2014;36:1244.
Carter BL, Doucette WR, Franciscus CL, et al. Deterioration of blood pressure control after discontinuation of a physicianâ€pharmacist collaborative intervention. Pharmacotherapy 2010;30:228-35.
Albsoul-Younes AM, Hammad EA, Yasein NA, Tahaineh LM. Pharmacist-physician collaboration improves blood pressure control. Saudi Med J 2011;32:288-92.
Wentzlaff DM, Carter BL, Ardery G, et al. Sustained blood pressure control following discontinuation of a pharmacist intervention. J Clin Hypertens 2011;13:431-7.
Zhao PX, Wang C, Qin L, et al. Effect of clinical pharmacists pharmaceutical care intervention to control hypertensive outpatients in China. Afr J Pharm Pharmacol 2012;6:48-56.
Morgado M, Rolo S, Castelo-Branco M. Pharmacist intervention program to enhance hypertension control: a randomised controlled trial. Int J Clin Pharm 2011;33:132-40.
Tsuyuki RT, Al Hamarneh YN, Jones CA, Hemmelgarn BR. The effectiveness of pharmacist interventions on cardiovascular risk: the multicenter randomized controlled RxEACH trial. J Am Coll Cardiol 2016;67:2846-54.
Carter BL, Vander Weg MW, Parker CP, et al. Sustained blood pressure control following discontinuation of a pharmacist intervention for Veterans. J Clin Hypertens 2015;17:701-8.
Stewart K, George J, Mc Namara KP, et al. A multifaceted pharmacist intervention to improve antihypertensive adherence: a clusterâ€randomized, controlled trial (HAPPy trial). J Clin Pharm Ther 2014;39:527-34.
Okada H, Onda M, Shoji M, et al. Effects of lifestyle advice provided by pharmacists on blood pressure: The COMmunity Pharmacists ASSist for Blood Pressure (COMPASS-BP) randomized trial. Biosci Trends 2017;11:632-9.
Morgado MP, Morgado SR, Mendes LC, et al. Pharmacist interventions to enhance blood pressure control and adherence to antihypertensive therapy: review and meta-analysis. Am J Health Syst Pharm 2011;68:241-53.
Santschi V, Chiolero A, Burnand B, et al. Impact of pharmacist care in the management of cardiovascular disease risk factors: a systematic review and meta-analysis of randomized trials. Arch Intern Med 2011;171:1441-53.
Bloch MJ. Recent data from National Health and Nutrition Examination Survey (NHANES) demonstrates no improvement in US blood pressure control rates. J Am Soc Hypertens 2018;12:3-4.
Von Muenster SJ, Carter BL, Weber CA, et al. Description of pharmacist interventions during physician-pharmacist co-management of hypertension. Pharm World Sci 2008;30:128-35.
Blenkinsopp A. Extended adherence support by community pharmacists for patients with hypertension: a randomised controlled trial. Int J Pharm Pract 2000;8:165-75.
Chabot I, Moisan J, Grégoire JP, Milot A. Pharmacist intervention program for control of hypertension. Ann Pharmacother 2003;37:1186-93.
Sookaneknun P, Richards RM, Sanguansermsri J, Teerasut C. Pharmacist involvement in primary care improves hypertensive patient clinical outcomes. Ann Pharmacother 2004;38:2023-8.
Stewart B, Brody A, Krishnan AC, et al. An unmet need meets an untapped resource: pharmacist-led pathways for hypertension management for emergency department patients. Curr Hypertens Rep 2019;21:61.
How to Cite
Meta-analysis of pharmacist-led and pharmacist-physician intervention on blood pressure control. (2021). Italian Journal of Medicine, 15(3). https://doi.org/10.4081/itjm.2021.1463
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