Meta-analysis of pharmacist-led and pharmacist-physician intervention on blood pressure control

Submitted: 12 January 2021
Accepted: 9 February 2021
Published: 24 September 2021
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Effective intervention is a significant component in the improvement of blood pressure control and patient adherence. Blood pressure control includes different self-monitoring techniques, mobile health monitoring, or healthcare professionals' interventions. This study aims to compare, analyze, and interpret the effectiveness of pharmacist-physician collaboration and pharmacist- led interventions. Meta-analysis was performed using MEDLINE via PubMed, EMBASE, EBSCO, Web of Science, Scopus, and the Cochrane Library databases between 2008-2018. Of the 51 relevant systematic reviews identified, 15 were of sufficient quality and included in the data synthesis. The breakdown of the 15 included 7 (n=2026) pharmacist and 8 pharmacist-physician interventions (n=2361). The impact of pharmacist-physician collaboration and pharmacist-led interventions on Systolic Blood Pressure was -8.22 (-11.01; -5.42) (P<0.01) and -7.68 (-9.30; -6.06) (P=0.35), respectively. On the other hand, similar correlation for Diastolic Blood Pressure for the impact of pharmacist-physician collaboration and pharmacist-led interventions was -3.55 (-4.54; -2.55) (P=0.49) and -2.58 (-3.76; -1.39) (P=0.24), respectively. These results suggest that both interventions are effective for blood pressure control. However, when two meta-analyses were compared, it was found that pharmacist-physician collaboration was more effective than pharmacist-led interventions. This finding highlights the importance of multidisciplinary approaches during blood pressure control procedures. When a holistic view is considered; especially cost-effectiveness, future studies must be diversified to encompass a broader context and impact analysis.

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World Health Organization Report. A Global brief of hypertension, World Health Day 2013, WHO/DCO/WHD/2013.2 2013. Available from: https://ish-world.com/downloads/pdf/global_brief_hypertension.pdf. Accessed: 2013.
Robitaille C, Dai S, Waters C, et al. Diagnosed hypertension in Canada: incidence, prevalence and associated mortality. CMAJ 2012;184:49-56. DOI: https://doi.org/10.1503/cmaj.101863
Kearney PM, Whelton M, Reynolds K, et al. Global burden of hypertension: analysis of worldwide data. Lancet 2005;365:217-23. DOI: https://doi.org/10.1016/S0140-6736(05)17741-1
Berenson GS. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med 1998;338:1650-6. DOI: https://doi.org/10.1056/NEJM199806043382302
Thompson DW, Furlan AJ. Clinical epidemiology of stroke. Neurol Clin 1996;14:309-15. DOI: https://doi.org/10.1016/S0733-8619(05)70258-9
Ong KL, Cheung BM, Man YB, et al. Prevalence, awareness, treatment, and control of hypertension among United States adults 1999-2004. Hypertension 2007;49:69-75. DOI: https://doi.org/10.1161/01.HYP.0000252676.46043.18
Go AS, Bauman MA, King SMC, et al. An effective approach to high blood pressure control: a science advisory from the American Heart Association, the American College of Cardiology, and the Centers for Disease Control and Prevention. J Am Coll Cardiol 2014;63:1230-8. DOI: https://doi.org/10.1161/HYP.0000000000000003
Borenstein JE, Graber G, Saltiel E, et al. Physician-pharmacist co-management of hypertension: a randomized, comparative trial. Pharmacotherapy 2003;23:209-16. DOI: https://doi.org/10.1592/phco.23.2.209.32096
Hunt JS, Siemienczuk J, Pape G, et al. A randomized controlled trial of team-based care: impact of physician-pharmacist collaboration on uncontrolled hypertension. J Gen Intern Med 2008;23:1966-72. DOI: https://doi.org/10.1007/s11606-008-0791-x
Carter BL, Ardery G, Dawson JD, et al. Physician and pharmacist collaboration to improve blood pressure control. Arch Intern Med 2009;169:1996-2002. DOI: https://doi.org/10.1001/archinternmed.2009.358
Carter BL, Rogers M, Daly J, et al. The potency of team-based care interventions for hypertension: a meta-analysis. Arch Intern Med 2009;169:1748-55. DOI: https://doi.org/10.1001/archinternmed.2009.316
Magid DJ, Olson KL, Billups SJ, et al. A pharmacist-led, American Heart Association Heart360 Web-enabled home blood pressure monitoring program. Circ Cardiovasc Qual Outcomes 2013;6:157-63. DOI: https://doi.org/10.1161/CIRCOUTCOMES.112.968172
Mancia G, Facchetti R, Bombelli M, et al. Long-term risk of mortality associated with selective and combined elevation in office, home, and ambulatory blood pressure. Hypertension 2006;47:846-53. DOI: https://doi.org/10.1161/01.HYP.0000215363.69793.bb
Margolis KL, Asche SE, Bergdall AR, et al. Effect of home blood pressure telemonitoring and pharmacist management on blood pressure control: a cluster randomized clinical trial. JAMA 2013;310:46-56. DOI: https://doi.org/10.1001/jama.2013.6549
Green BB, Cook AJ, Ralston JD, et al. Effectiveness of home blood pressure monitoring, Web communication, and pharmacist care on hypertension control: a randomized controlled trial. JAMA 2008;299:2857-67. DOI: https://doi.org/10.1001/jama.299.24.2857
Chisholm-Burns MA, Lee JK, Spivey CA, et al. US pharmacists’ effect as team members on patient care: systematic review and meta-analyses. Med Care 2010;923-33. DOI: https://doi.org/10.1097/MLR.0b013e3181e57962
Frail CK, Cooper S, Gallagher T, et al. A technology-supported collaboration between a health plan and a community pharmacy to improve blood pressure control. J Am Pharm Assoc 2017;57:630-4. DOI: https://doi.org/10.1016/j.japh.2017.05.013
Koshman SL, Charrois TL, Simpson SH, et al. Pharmacist care of patients with heart failure: a systematic review of randomized trials. Arch Intern Med 2008;168:687-94. DOI: https://doi.org/10.1001/archinte.168.7.687
Namara KPM, Dunbar JA, Philpot B, et al. Potential of pharmacists to help reduce the burden of poorly managed cardiovascular risk. Aust J Rural Health 2012;20:67-73. DOI: https://doi.org/10.1111/j.1440-1584.2012.01259.x
Fikri-Benbrahim N, Faus MJ, Martínez-Martínez F, Sabater-Hernández D. Impact of a community pharmacists’ hypertension-care service on medication adherence. The AFenPA study. Res Social Adm Pharm 2013;9:797-805. DOI: https://doi.org/10.1016/j.sapharm.2012.12.006
Yarnall KS, Østbye T, Krause KM, et al. Peer reviewed: family physicians as team leaders: ‘time’ to share the care. Prev Chronic Dis 2009;6:59.
Santschi V, Chiolero A, Colosimo AL, et al. Improving blood pressure control through pharmacist interventions: a meta-analysis of randomized controlled trials. J Am Heart Assoc 2014;3:e000718. DOI: https://doi.org/10.1161/JAHA.113.000718
Altowaijri A, Phillips CJ, Fitzsimmons D. A systematic review of the clinical and economic effectiveness of clinical pharmacist intervention in secondary prevention of cardiovascular disease. J Manage Care Pharm 2013;19:408-16. DOI: https://doi.org/10.18553/jmcp.2013.19.5.408
Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Int J Surg 2010;8:336-41. DOI: https://doi.org/10.1016/j.ijsu.2010.02.007
Hutton B, Salanti G, Caldwell DM, et al. The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med 2015;162:777-84. DOI: https://doi.org/10.7326/M14-2385
Higgins JPT, Green S. Cochrane handbook for systematic reviews of interventions. Chichester, West Sussex, UK; Hoboken NJ: Wiley-Blackwell; 2008. DOI: https://doi.org/10.1002/9780470712184
Smith SM, Carris NW, Dietrich E, et al. Physician-pharmacist collaboration versus usual care for treatment-resistant hypertension. J Am Soc Hypertens 2016;10:307-17. DOI: https://doi.org/10.1016/j.jash.2016.01.010
Carter BL, Bergus GR, Dawson JD, et al. A cluster randomized trial to evaluate physician/pharmacist collaboration to improve blood pressure control. J Clin Hypertens 2008;10:260-71. DOI: https://doi.org/10.1111/j.1751-7176.2008.07434.x
Polgreen LA, Han J, Carter BL, et al. Cost-effectiveness of a physician–pharmacist collaboration intervention to improve blood pressure control. Hypertension 2015;66:1145-51. DOI: https://doi.org/10.1161/HYPERTENSIONAHA.115.06023
Hirsch JD, Steers N, Adler DS, et al. A randomized pragmatic trial of primary care based pharmacist-physician collaborative medication therapy management for hypertension. Clin Ther 2014;36:1244. DOI: https://doi.org/10.1016/j.clinthera.2014.06.030
Carter BL, Doucette WR, Franciscus CL, et al. Deterioration of blood pressure control after discontinuation of a physicianâ€pharmacist collaborative intervention. Pharmacotherapy 2010;30:228-35. DOI: https://doi.org/10.1592/phco.30.3.228
Albsoul-Younes AM, Hammad EA, Yasein NA, Tahaineh LM. Pharmacist-physician collaboration improves blood pressure control. Saudi Med J 2011;32:288-92.
Wentzlaff DM, Carter BL, Ardery G, et al. Sustained blood pressure control following discontinuation of a pharmacist intervention. J Clin Hypertens 2011;13:431-7. DOI: https://doi.org/10.1111/j.1751-7176.2011.00435.x
Zhao PX, Wang C, Qin L, et al. Effect of clinical pharmacists pharmaceutical care intervention to control hypertensive outpatients in China. Afr J Pharm Pharmacol 2012;6:48-56. DOI: https://doi.org/10.5897/AJPP11.633
Morgado M, Rolo S, Castelo-Branco M. Pharmacist intervention program to enhance hypertension control: a randomised controlled trial. Int J Clin Pharm 2011;33:132-40. DOI: https://doi.org/10.1007/s11096-010-9474-x
Tsuyuki RT, Al Hamarneh YN, Jones CA, Hemmelgarn BR. The effectiveness of pharmacist interventions on cardiovascular risk: the multicenter randomized controlled RxEACH trial. J Am Coll Cardiol 2016;67:2846-54. DOI: https://doi.org/10.1016/j.jacc.2016.03.528
Carter BL, Vander Weg MW, Parker CP, et al. Sustained blood pressure control following discontinuation of a pharmacist intervention for Veterans. J Clin Hypertens 2015;17:701-8. DOI: https://doi.org/10.1111/jch.12577
Stewart K, George J, Mc Namara KP, et al. A multifaceted pharmacist intervention to improve antihypertensive adherence: a clusterâ€randomized, controlled trial (HAPPy trial). J Clin Pharm Ther 2014;39:527-34. DOI: https://doi.org/10.1111/jcpt.12185
Okada H, Onda M, Shoji M, et al. Effects of lifestyle advice provided by pharmacists on blood pressure: The COMmunity Pharmacists ASSist for Blood Pressure (COMPASS-BP) randomized trial. Biosci Trends 2017;11:632-9. DOI: https://doi.org/10.5582/bst.2017.01256
Morgado MP, Morgado SR, Mendes LC, et al. Pharmacist interventions to enhance blood pressure control and adherence to antihypertensive therapy: review and meta-analysis. Am J Health Syst Pharm 2011;68:241-53. DOI: https://doi.org/10.2146/ajhp090656
Santschi V, Chiolero A, Burnand B, et al. Impact of pharmacist care in the management of cardiovascular disease risk factors: a systematic review and meta-analysis of randomized trials. Arch Intern Med 2011;171:1441-53. DOI: https://doi.org/10.1001/archinternmed.2011.399
Bloch MJ. Recent data from National Health and Nutrition Examination Survey (NHANES) demonstrates no improvement in US blood pressure control rates. J Am Soc Hypertens 2018;12:3-4. DOI: https://doi.org/10.1016/j.jash.2017.11.003
Von Muenster SJ, Carter BL, Weber CA, et al. Description of pharmacist interventions during physician-pharmacist co-management of hypertension. Pharm World Sci 2008;30:128-35. DOI: https://doi.org/10.1007/s11096-007-9155-6
Blenkinsopp A. Extended adherence support by community pharmacists for patients with hypertension: a randomised controlled trial. Int J Pharm Pract 2000;8:165-75. DOI: https://doi.org/10.1111/j.2042-7174.2000.tb01002.x
Chabot I, Moisan J, Grégoire JP, Milot A. Pharmacist intervention program for control of hypertension. Ann Pharmacother 2003;37:1186-93. DOI: https://doi.org/10.1345/aph.1C267
Sookaneknun P, Richards RM, Sanguansermsri J, Teerasut C. Pharmacist involvement in primary care improves hypertensive patient clinical outcomes. Ann Pharmacother 2004;38:2023-8. DOI: https://doi.org/10.1345/aph.1D605
Stewart B, Brody A, Krishnan AC, et al. An unmet need meets an untapped resource: pharmacist-led pathways for hypertension management for emergency department patients. Curr Hypertens Rep 2019;21:61. DOI: https://doi.org/10.1007/s11906-019-0965-4

How to Cite

Memisoglu, M., & Çelik, Y. (2021). Meta-analysis of pharmacist-led and pharmacist-physician intervention on blood pressure control. Italian Journal of Medicine, 15(3). https://doi.org/10.4081/itjm.2021.1463

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