Original Articles
4 April 2024
Vol. 18 No. 2 (2024)
Strong association between angiotensin I-converting enzyme insertion/deletion polymorphism and unexplained recurrent spontaneous abortion of Sudanese women: a case-control study
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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This study investigated the link between angiotensin I-converting enzyme insertion/deletion (ACE I/D) polymorphism and unexplained spontaneous abortion. This retrospective analytical case-control was conducted at the Omdurman Maternity Hospital in Sudan. The current study contained 230 individuals, including 119 cases (women who had at least three abortions) of unknown cause and 119 controls (healthy women who had at least two full-term deliveries without spontaneous abortion). Patients and controls were provided five ml of ethylenediaminetetraacetic acid blood and answered questionnaires about their demographics, personal lives, and family histories. ACE I/D polymorphisms were assessed using a conventional polymerase chain reaction approach after total genomic DNA was isolated from blood leukocytes using the GF-1 blood DNA extraction kit. Data was analyzed using the Statistical Package for the Social Sciences version 24. ACE I/D polymorphism is strongly linked to unexplained spontaneous abortion, and women with the I/D and D/D genotypes are more likely to have it than those with the I/I genotype. The current study reveals that ACEI/D polymorphism increases pregnancy problems. Sudanese women may have spontaneous abortions due to the ACE I/D polymorphism.
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Deng T, Liao X, Zhu S. Recent Advances in Treatment of Recurrent Spontaneous Abortion. Obstet Gynecol Surv 2022;77:355-66. DOI: https://doi.org/10.1097/OGX.0000000000001033
Turesheva A, Aimagambetova G, Ukybassova T, et al. Recurrent pregnancy loss etiology, risk factors, diagnosis, and management. fresh look into a full box. J Clin Med 2023;12:4074. DOI: https://doi.org/10.3390/jcm12124074
Cao C, Bai S, Zhang J, et al. Understanding recurrent pregnancy loss: recent advances on its etiology, clinical diagnosis, and management. Med Rev 2022;2:570-89. DOI: https://doi.org/10.1515/mr-2022-0030
Hyde KJ, Schust DJ. Genetic considerations in recurrent pregnancy loss. Cold Spring Harb Perspect Med 2015;5:a023119. DOI: https://doi.org/10.1101/cshperspect.a023119
Thakur S, Sharma V, Kaur D, Purkait P. Angiotensin-Converting Enzyme (ACE) Insertion/Deletion (I/D) Polymorphism as a Conjoint Regulator of Coagulation, Fibrinolytic, and RAAS Pathway in Infertility and Associated Pregnancy Complications. J Renin Angiotensin Aldosterone Syst 2022;2022:1695769.
Thakur S, Sharma V, Kaur D, Purkait P. Angiotensin-Converting Enzyme (ACE) Insertion/Deletion (I/D) Polymorphism as a Conjoint Regulator of Coagulation, Fibrinolytic, and RAAS Pathway in Infertility and Associated Pregnancy Complications. J Renin Angiotensin Aldosterone Syst 2022;2022:1695769. DOI: https://doi.org/10.1155/2022/1695769
Vladeanu MC, Bararu Bojan I, Bojan A, et al. Angiotensin-converting enzyme gene D-allele and the severity of coronary artery disease. Exp Ther Med 2020;20:3407-11. DOI: https://doi.org/10.3892/etm.2020.8978
Gintoni I, Adamopoulou M, Yapijakis C. The angiotensin-converting enzyme insertion/deletion polymorphism as a common risk factor for major pregnancy complications. In vivo (Athens, Greece) 2021;35:95-103. DOI: https://doi.org/10.21873/invivo.12236
Babker AM, Gameel FE. Methylenetetrahydrofolate reductase c677t polymorphism in Sudanese women with recurrent spontaneous abortions. Kuwait Med J 2016;48:100-4.
Babker AM, Gameel FE. Molecular Characterization of Prothrombin G20210A gene Mutations In pregnant Sudanese women with spontaneous recurrent abortions. Rawal Med J 2015;40:207-9.
Zhang S, Wang J, Wang B, et al. Strong association between angiotensin I-converting enzyme I/D polymorphism and unexplained recurrent miscarriage of Chinese women--a case-control study. Reprod Sci 2011;18:743-6. DOI: https://doi.org/10.1177/1933719111415865
Kim JJ, Choi YM, Lee SK, et al. The PAI‐1 4G/5G and ACE I/D polymorphisms and risk of recurrent pregnancy loss: a case-control study. Am J Reprod Immunol 2014;72:571-6. DOI: https://doi.org/10.1111/aji.12302
Su MT, Lin SH, Chen YC, Kuo PL. Genetic association studies of ACE and PAI-1 genes in women with recurrent pregnancy loss: a systematic review and meta-analysis. Thromb Haemost 2013;109:8-15. DOI: https://doi.org/10.1160/TH12-08-0584
Li H, Ma Y, Fu Q, Wang L. Angiotensin-converting enzyme insertion/deletion (ACE I/D) and angiotensin II type 1 receptor (AT1R) gene polymorphism and its association with preeclampsia in Chinese women. Hypertens Pregnancy 2007;26:293-301. DOI: https://doi.org/10.1080/10641950701413676
Goodman C, Hur J, Goodman CS, et al. Are polymorphisms in the ACE and PAI-1 genes associated with recurrent spontaneous miscarriages? Am J Reprod Immunol 2009;62:365-70. DOI: https://doi.org/10.1111/j.1600-0897.2009.00744.x
Shakarmi F, Akbari MT, ZareKarizi SH, Ajamian F. Association of angiotensin converting enzyme (ACE), D/I polymorphisms with recurrent pregnancy loss. Armaghane Danesh. 2014;19:442-9.
Fageer Hussian AM, Ali Mohammed NE, Mohamed Ahmed MA, Widaa Ali E. Angiotensin Converting Enzyme Insertion/Deletion (I/D) Polymorphism and Risk of Recurrent Pregnancy Loss among Sudanese Women. Res Obstet Gynecol 2016;4:7-10.
Al-Mukaynizi FB, AlKhuriji A, Bebay Z, et al. Lack of Association between Angiotensin Converting Enzyme I/D Polymorphism and Unexplained Recurrent Miscarriage in Saudi Arabia. J Med Biochem 2016;35:166-73. DOI: https://doi.org/10.1515/jomb-2015-0020
How to Cite
Strong association between angiotensin I-converting enzyme insertion/deletion polymorphism and unexplained recurrent spontaneous abortion of Sudanese women: a case-control study. (2024). Italian Journal of Medicine, 18(2). https://doi.org/10.4081/itjm.2024.1717
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