Sex differences in adverse drug reaction and liver disease

Submitted: 7 June 2017
Accepted: 8 January 2018
Published: 20 March 2018
Abstract Views: 1872
PDF: 766
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Adverse drug reactions represent a significant public health problem. A share of no small adverse reaction is particularly serious and can even lead to patient's death. Furthermore, hepatitis induced by serious drug reactions is a rare event but potentially fatal. Finally, we know that epidemiological studies have highlighted male gender as an independent predictor of fibrosis progression towards cirrhosis in hepatitis B and C-virus, as well as non-alcoholic steatohepatitis. The importance of considering the differences between the male and female sex in clinical decision-making is crucial. The physiopathology of liver disease is different in the two genres, but these differences are not yet fully known and several potential mechanisms have been identified.

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Para, O., Crispino, P., Barone, N., Macis, S., Airasca, L., Gnerre, P., & Politi, C. (2018). Sex differences in adverse drug reaction and liver disease. Italian Journal of Medicine, 12(1), 15–22. https://doi.org/10.4081/itjm.2018.893

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