Severe paraneoplastic hypoglycemia due to a non-islet cell tumor in a patient with an advanced gastrointestinal stromal tumor

Submitted: 14 March 2020
Accepted: 17 April 2020
Published: 19 May 2020
Abstract Views: 625
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Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract, mainly localized in the stomach. Most GISTs derive from mutations in tyrosine kinase receptors or platelet-derived growth factor receptor-α. GISTs are rarely associated with paraneoplastic hypoglycemia caused by a non-β-cells tumor. This syndrome, defined non-islet cell tumor hypoglycemia (NICTH), arises from excess tumor production of insulin-like growth factor. We describe the case of a 67-year-old female with severe NICTH secondary to an advanced and metastatic GIST.

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Federico Vancheri, Internal Medicine, S. Elia Hospital, Caltanissetta

Internal Medicine, consultant

How to Cite

Alletto, M., Burgio, A., Fulco, G., Geraci, G., Groppuso, C., Gruttadauria, G., Manfrè, E., Mastrosimone, G., Salvaggio, S., Urrico, G., & Vancheri, F. (2020). Severe paraneoplastic hypoglycemia due to a non-islet cell tumor in a patient with an advanced gastrointestinal stromal tumor. Italian Journal of Medicine, 14(3), 167–171. https://doi.org/10.4081/itjm.2020.1276