Cardiac amyloidosis: a review of the literature and a practical approach for the clinicians

  • Annalisa Angelini | annalisa.angelini@unipd.it Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padua, Italy.
  • Francesca Zanco Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padua, Italy.
  • Chiara Castellani Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padua, Italy.
  • Andrea Di Francesco Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padua, Italy.
  • Mila Della Barbera Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padua, Italy.
  • Giovanni Maria Vescovo Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padua, Italy.
  • Tamara Berno Department of Medicine, Hematology and Clinical Immunology Unit, University of Padua, Italy.
  • Marny Fedrigo Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padua, Italy.

Abstract

Amyloidosis is a group of progressive and devastating disorders resulting from misfolded proteins extracellular deposition into tissues. When deposition of fibrils occurs in cardiac tissues, this systemic disease can lead to a very poor prognosis. In this review, we focused on the most common types of cardiac amyloidosis and their treatments. Early diagnosis remains critically important, and here we reviewed the diagnostic methods adopted starting from the non-invasive imaging techniques to more invasive approaches, and the typing of precursor proteins. Typing the different misfolding proteins is mandatory since therapy differs accordingly and thus guiding therapy. We highlighted the most updated and recent treatment strategies to cure amyloidosis.

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Published
2019-06-18
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State of the Art with an Expert
Keywords:
Systemic amyloidosis, cardiac amyloidosis, proteomic, mass spectrometry.
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How to Cite
Angelini, A., Zanco, F., Castellani, C., Di Francesco, A., Della Barbera, M., Vescovo, G. M., Berno, T., & Fedrigo, M. (2019). Cardiac amyloidosis: a review of the literature and a practical approach for the clinicians. Italian Journal of Medicine, 13(2), 73-90. https://doi.org/10.4081/itjm.2019.1149