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Mean platelet volume as diagnostic and therapeutic marker of risk and prognosis of heart disease

Henshaw Uchechi Okoroiwu, Christopher Ogar Ogar
  • Henshaw Uchechi Okoroiwu
    Hematology Unit, Department of Medical Laboratory Science, University of Calabar, Nigeria | okoroiwuhenshaw@gmail.com
  • Christopher Ogar Ogar
    Hematology Unit, Department of Medical Laboratory Science, University of Calabar, Nigeria

Abstract

Increased mean platelet volume (MPV) is associated with platelet reactivity and is a predictor of cardiovascular risk and unprovoked nervous thromboembolism. Mean platelet volume is a precise measure of platelet size. Studies have reported the use of MPV as a biomarker for predicting ischemic stroke in atrial fibrillation patients as well as in anticoagulant prescription and rhythm-control therapy. Moreover, MPV may predict cardiovascular event outcome following percutaneous coronary intervention in patients with coronary artery disease. MPV may predict residual platelet reactivity in dual antiplatelet therapy. Factors influencing MPV result were discussed. This review centered on the reports that MPV may be a biomarker of risk and prognosis of prevalent heart diseases.

Keywords

Mean platelet volume; cardiovascular disease; atrial fibrillation; myocardial infarction; biomarker.

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Submitted: 2017-08-20 22:55:32
Published: 2018-01-11 00:00:00
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Copyright (c) 2018 Henshaw Uchechi Okoroiwu, Christopher Ogar Ogar

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