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Sex differences in adverse drug reaction and liver disease

Ombretta Para, Pietro Crispino, Nunzia Barone, Sara Macis, Laura Airasca, Paola Gnerre, Cecilia Politi
  • Pietro Crispino
    Department of Internal Medicine, San Carlo Hospital, Potenza, Italy
  • Nunzia Barone
    Department of Internal Medicine, San Carlo Hospital, Potenza, Italy
  • Sara Macis
    Hospital Pharmacy, San Paolo Hospital, Savona, Italy
  • Laura Airasca
    Hospital Pharmacy, San Paolo Hospital, Savona, Italy
  • Paola Gnerre
    Department of Internal Medicine, San Paolo Hospital, Savona, Italy
  • Cecilia Politi
    Department of Internal Medicine, Hospital of Isernia, Italy

Abstract

Adverse drug reactions represent a significant public health problem. A share of no small adverse reaction is particularly serious and can even lead to patient’s death. Furthermore, hepatitis induced by serious drug reactions is a rare event but potentially fatal. Finally, we know that epidemiological studies have highlighted male gender as an independent predictor of fibrosis progression towards cirrhosis in hepatitis B and C-virus, as well as non-alcoholic steatohepatitis. The importance of considering the differences between the male and female sex in clinical decision-making is crucial. The physiopathology of liver disease is different in the two genres, but these differences are not yet fully known and several potential mechanisms have been identified.

Keywords

Adverse drug reactions; drug-induced liver injury; liver disease; chronic hepatitis.

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Submitted: 2017-06-07 20:16:19
Published: 2018-03-20 17:25:07
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Copyright (c) 2018 Ombretta Para, Pietro Crispino, Nunzia Barone, Sara Macis, Laura Airasca, Paola Gnerre, Cecilia Politi

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