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Endothelial dysfunction and reduced heart rate variability in patients with metabolic syndrome

Elena Nikolaevna Smirnova, Evgeniya Alexandrovna Loran, Sofia Grigorievna Shulkina, Sergey Yurievich Podtaev, Maxim Victorovich Trushin
  • Elena Nikolaevna Smirnova
    Perm State Medical University named after Academician E.A. Vagner, Russian Ministry of Health, Perm; Institute of Continuous Media Mechanics, Ural Branch of Russian Academy of Science, Perm, Russian Federation
  • Evgeniya Alexandrovna Loran
    Perm State Medical University named after Academician E.A. Vagner, Russian Ministry of Health, Perm; Institute of Continuous Media Mechanics, Ural Branch of Russian Academy of Science, Perm, Russian Federation
  • Sofia Grigorievna Shulkina
    Perm State Medical University named after Academician E.A. Vagner, Russian Ministry of Health, Perm; Institute of Continuous Media Mechanics, Ural Branch of Russian Academy of Science, Perm, Russian Federation
  • Sergey Yurievich Podtaev
    Perm State Medical University named after Academician E.A. Vagner, Russian Ministry of Health, Perm; Institute of Continuous Media Mechanics, Ural Branch of Russian Academy of Science, Perm, Russian Federation
  • Maxim Victorovich Trushin
    Kazan Federal University, Kazan, Russian Federation | mtrushin@mail.ru

Abstract

According to experts of the World Health Organization (WHO), metabolic syndrome (MS) can be considered as pandemy of the XXI century, because its prevalence among the population of developed countries is about 25-35%. In this study with the purpose of complex investigation of the autonomic nervous system and endothelial function we included 66 patients with MS between the ages of 25 and 61 (46.9±9.9 years). A comparison group of apparently healthy individuals (16 individuals, average age of 45.3±2.3 years; P>0.05) was studied. To evaluate the response of microvascular tone, we used the method of wavelet analysis of skin temperature oscillations during cooling of the limb. All patients underwent the study of heart rate variability. The levels of insulin, endothelin-1, and vascular endothelial growth factor were determined using enzyme immunoassay. Patients with MS had significant differences in all metabolic parameters. Our study showed that in the group of MS there is a decrease of the variability of heart rhythm compared with the healthy group. Conducting cold test revealed signs of endothelial dysfunction in the MS group, which was manifested by the decrease of the index of vasodilation in the endothelial and neurogenic frequency range. In the study group we determined the increase in biochemical markers of endothelial dysfunction, which correlated with parameters of vasodilation. Also, the presence of endothelial dysfunction significantly correlated with signs of reduction of the variability of the heart rhythm.

Keywords

Metabolic syndrome; endothelial dysfunction; cold test; heart rate variability.

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Submitted: 2017-02-07 18:12:14
Published: 2018-03-20 17:25:08
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Copyright (c) 2018 Elena Nikolaevna Smirnova, Evgeniya Alexandrovna Loran, Sofia Grigorievna Shulkina, Sergey Yurievich Podtaev, Maxim Victorovich Trushin

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