Management of celiac disease: from evidence to clinical practice

Main Article Content

Tiziana M. Attardo *
Elena Magnani
Carlotta Casati
Danilo Cavalieri
Pietro Crispino
Federica Fascì Spurio
Stefano De Carli
Daniela Tirotta
Paola Gnerre
(*) Corresponding Author:
Tiziana M. Attardo | claudia.fantucchio@alice.it

Abstract

Celiac disease (CD) is a complex polygenic disorder, which involves genetic factors human leukocyte complex (HLA) and non-HLA genes, environmental factors, innate and adoptive immunity, and a robust chronic T-mediated autoimmune component. The main goal of the present monograph is to define a methodological approach for the disease, characterized by frequent late diagnosis, in order for the physician to become aware of the disease management, the diversity of the clinical presentation itself and in different patients. A unique attention is payed to the specific diagnostic tests to define a correct and accurate application of them, and in addition, to disease follow-up and possible complications. Moreover, a dedicated space is assigned to refractory CD, to potential CD and non-celiac gluten sensitivity. Legislative aspects of the celiac disease in Italy are addressed, too. The celiac disease guidelines and their evaluation by means of Appraisal of Guidelines, Research and Evaluation II instrument allow us to classify the different recommendations and to apply them according to the stakeholders’ involvement, pertinence, methodological accuracy, clarity and publishing independence. Finally, the most current scientific evidence is taken into account to create a complete updated monograph.

Downloads month by month

Downloads

Download data is not yet available.

Article Details

Author Biographies

Tiziana M. Attardo, Department of Internal Medicine, Barone Lombardo Hospital, Canicattì (AG)

MD  - Medicina Interna - Canicattì

Elena Magnani, Department of Internal Medicine, M. Bufalini Hospital, AUSL Romagna, Cesena (FC)

MD - Department of Internal Medicine, M. Bufalini Hospital, Cesena AUSL Romagna

Carlotta Casati, Department of Internal Medicine, Careggi Hospital, Firenze

MD, Department of Internal Medicine, Careggi Hospital, Firenze

Danilo Cavalieri, School of Specialization in Internal Medicine, Campus Bio-Medico University, Roma

MD, School of Specialisation in Medicine Interne,  Campus Bio-Medico -  Roma

Pietro Crispino, Department of Internal Medicine and Emergency, Lagonegro Hospital, ASP Potenza, Lagonegro (PZ)

MD, Department of Internal Medicine and Emergency, Di Lagonegro Hospital (PZ), ASP Potenza

Federica Fascì Spurio, Department of Internal Medicine, Dell’Angelo Hospital, Asl 12 Veneziana, Mestre (VE)

MD, Department of Internal Medicine, Dell'Angelo Hospital di Mestre, Asl 12 Veneziana 

Stefano De Carli, Department of Internal Medicine, S. Maria della Misericordia Hospital, Udine

MD, SOC 2^ Department of Internal Medicine, S. Maria della Misericordia Hospital, ASUI di Udine

Daniela Tirotta, Department of Internal Medicine, Cervesi Hospital, AUSL Romagna, Cattolica (RN)

MD, Department of Internal Medicine, Cervesi Hospital, Cattolica (RN), AUSL Romagna

Paola Gnerre, Department of Internal Medicine 2, San Paolo Hospital, Savona

MD, Department of Internal Medicine  2, San Paolo Hospital,  Savona.

 

Most read articles by the same author(s)