Autoimmune liver diseases: internist’s guide from bench to bedside

  • Mario Visconti | mario.visconti1@tin.it Department of Internal Medicine, Santa Maria del Popolo degli Incurabili Hospital, Naples, Italy.

Abstract

Autoimmune liver diseases are disorders of unknown etiology and immune pathogenesis, characterized by liver parenchyma inflammation (autoimmune hepatitis) or by lesions of the intralobular biliary ducts (primary biliary cirrhosis) or of the entire biliary system (primary sclerosing cholangitis). They differ with regard to the epidemiological, clinical, morphological and serological features; the possible evolution; the different associations with other immune diseases of the digestive or extra-digestive organs; the treatment options. All progressively can result in hepatic cirrhosis. More recently, overlap syndromes have been identified, in which patients exhibit overlapping clinical, morphological and serological features of the above indicated diseases. The frequency of overlap syndromes is progressively increasing, causing additional clinical difficulties. Here, I review the diagnostic and clinical problems of the definite autoimmune liver diseases and of the overlap syndromes, with more regard to the evidences that drive current practice.

Downloads

Download data is not yet available.
Published
2015-03-20
Section
Reviews
Keywords:
autoimmune liver diseases, autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis, overlap syndromes.
Statistics
Abstract views: 1156

PDF: 665
HTML: 2184
Share it

PlumX Metrics

PlumX Metrics provide insights into the ways people interact with individual pieces of research output (articles, conference proceedings, book chapters, and many more) in the online environment. Examples include, when research is mentioned in the news or is tweeted about. Collectively known as PlumX Metrics, these metrics are divided into five categories to help make sense of the huge amounts of data involved and to enable analysis by comparing like with like.

How to Cite
Visconti, M. (2015). Autoimmune liver diseases: internist’s guide from bench to bedside. Italian Journal of Medicine, 9(1), 20-36. https://doi.org/10.4081/itjm.2015.508