Differential diagnoses in COVID-19 pandemic: a retrospective descriptive study

Submitted: 26 October 2020
Accepted: 24 November 2020
Published: 23 December 2020
Abstract Views: 1209
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Since February 2020, severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) infection rapidly spread across Southern Switzerland. The available literature on differential diagnoses of coronavirus 2019 (COVID-19) is scarce. Our study aims to review differential diagnoses of SARS-CoV-2 infections in public hospitals in Southern Switzerland and describe patients' related outcomes. Between 01.03.2020 and 15.04.2020, 344 patients had a chest computed tomography-scan at admission, 210 of them were pathological. 172 patients had a positive nasopharyngeal swab for SARS-CoV-2, and 38 patients needed an additional diagnostic work-up and were included in this study. Among the selected patients, 8 underwent 2 polymerase chain reaction (PCR) for SARS-CoV-2, while 18 patients were subjected to 3 PCR. We observed 29 infective cases, 3 due to cardiovascular etiologies, 2 due to chronic obstructive pulmonary disease exacerbation, 1 due to cryptogenic organizing pneumonia, 3 not related to respiratory diseases. Our results highlight the importance of differential diagnosis in times of widespread occurrence of COVID-19, considering the similarity of symptoms and imaging appearance with other respiratory conditions.



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Ufficio Federale della Sanità Pubblica. Press communication; 2020. Available from: https://www.bag.admin.ch/bag/it/home/das-bag/aktuell/medienmitteilungen.msg-id-78233.html Accessed: 23 August 2020.
COVID-19 information for Switzerland; 2020. Available from: https://www.corona-data.ch/ Accessed: 23 August 2020.
Rigamonti E, Salera D, Gheorghiu AC, Gianella P. The many faces of interstitial pneumonia: a case of presumed SARS-CoV-2 infection. Swiss Med Wkly 2020;150:w20312. DOI: https://doi.org/10.4414/smw.2020.20312
MacIntyre CR, Chughtai AA, Barnes M, et al. The role of pneumonia and secondary bacterial infection in fatal and serious outcomes of pandemic influenza a (H1N1). BMC Infect Dis 2018;18:637. DOI: https://doi.org/10.1186/s12879-018-3548-0
Houlihan CF, Patel S, Price DA, et al. A/N1N1 flu pandemic. Life threatening infections labelled swine flu. BMJ 2010;340:c137. DOI: https://doi.org/10.1136/bmj.c137
Arashiro T, Nakamura S, Asami T, et al. SARS-CoV-2 and Legionella Co-infection in a person returning from a Nile Cruise. J Travel Med 2020;27:taa053. DOI: https://doi.org/10.1093/jtm/taaa053
Li-Ru C, Zheng-Xin C, Yang-Chun L, et al. Pulmonary contusion mimicking COVID-19: a case-report. World J Clin Cases 2020;8:1554-60. DOI: https://doi.org/10.12998/wjcc.v8.i8.1554
Wei-Cai D, Han-Wen Z, Jaun Y, et al. CT imaging and differential diagnosis of COVID-19. Can Assoc Radiol J 2020;71:195-200. DOI: https://doi.org/10.1177/0846537120913033
Hani C, Trieu NH, Saab I, et al. COVID-19 pneumonia: a review of typical CT findings and differential diagnosis. Diagn Interv Imaging 2020;101:263-8. DOI: https://doi.org/10.1016/j.diii.2020.03.014
Bordi L, Nicastri E, Scorzolini L, et al. Differential diagnosis of illness in patients under investigation for the novel coronavirus (SARS-CoV-2) Italy February 2020. Euro Surveill 2020;25:pii=2000170. DOI: https://doi.org/10.2807/1560-7917.ES.2020.25.8.2000170
Colaneri M, Sacchi P, Zuccaro V, et al. Clinical characteristics of coronavirus disease (COVID-19) early findings from a teaching hospital in Pavia, North Italy, 21 to 28 February 2020. Euro Surveill 2020;25:pii=2000460. DOI: https://doi.org/10.2807/1560-7917.ES.2020.25.16.2000460

How to Cite

Rigamonti, E., Fusi-Schmidhauser, T., Argentieri, G., & Gianella, P. (2020). Differential diagnoses in COVID-19 pandemic: a retrospective descriptive study. Italian Journal of Medicine, 15(1). https://doi.org/10.4081/itjm.2020.1410

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