P34 | Erythrodermia in Internal Medicine: clinical features and outcomes in a monocentric series

R. Capecchi¹, S. Barsotti¹, G. Bini¹, F. Masi², F. Finizola³, C. Cois², E. Citi¹, G. Linsalata¹, C. Giani¹, J. Rosada¹ | ¹Azienda USL Toscana Nordovest, Pisa, (Livorno), ²University of Pisa, ³Azienda USL Toscana Nordovest, Pisa, (Fivizzano), Italy

Abstract

Premises and Purpose of the study: We present a retrospective monocentric study of erythrodermic patients in our Internal Medicine Unit.
Materials and Methods: Twenty-eight patients with a diagnosis of erythrodermia were hospitalized in our Unit from 2011 to present. For eighteen ones clinical data were available.
Results: Patients mean age was 83 (±8 SD), 10 were man. Mean days of hospitalization were 9 days (±4). In eleven cases, a drug allergy was find (3 vs. amoxicillin/clavulanic acid, 3 vs. fluorquinolones, other reactions were described with carbamazepine, hydroxychloroquine, fenobarbital, acyclovir, dutasteride). Five patients presented psoriasis, 7 had an oncological history record, while 9 patients presented sepsis. In our series no hypereosinophilia was described (mean eosinophils were 350/μl±396), while neutrophilia and high WBC were more common findings (9300/μl±5204 and 11550/μl±5895, respectively). CPR was also elevated (4,56±7,52), while transaminases were normal. Patients were treated with steroids and antihistamines after drug suspension, with a mean equivalent prednisone dose of 39,65 mg/die (±26,55) at discharge.
Conclusions: Erythrodermia is a potentially dangerous condition in elderly patients with sepsis, often caused by drug allergy. An accurate anamnesis and a prompt allergic evaluation can improve clinical management and reduce hospital burden.