CO15 | A single-center experience in screening patients for carbapenem-resistant enterobacteriaceae at admission
C. Fonnesu1, M.A. Distasi2, R. Napoletano3, R. Bruno4, R. D’errico1, A. Crapolicchio4, M. Frualdo1, A. Quarticelli1, L. Ceci5, S. Lenti6 | 1Dirigente Medico, UOC Medicina Interna, Ospedale Lorenzo Bonomo, Andria, ASL BAT, 2Dirigente Medico, UOC Patologia Clinica, Ospedale Lorenzo Bonomo, Andria, ASL BAT, 3Scuola di Specializzazione di Medicina Interna, Ospedali Riuniti di Foggia, 4Dirigente Biologo, UOC Patologia Clinica, Ospedale Lorenzo Bonomo, Andria, ASL BAT, 5Direttore, UOCPatologia Clinica, Ospedale Lorenzo Bonomo, Andria, ASL BAT, 6Direttore, UOC Medicina Interna, Ospedale Lorenzo Bonomo, Andria, ASL BAT, Italy
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Background and Aims: Bloodstream infections due to carbapenem-resistant enterobacteriaceae (CRE) is a leading cause of morbidity and mortality. Our aim was to investigate the prevalence of colonization from CRE among patients admitted to Internal Medicine Unit.
Materials and Methods: We retrospectively collected rectal swab specimens from patients at admission between November and December 2023. Laboratory searched for gram negative resistance markers analysing rectal samples with multiplex PCR-based BD MAX assay to detect the 5 major carbapenemase families (OXA-48, VIM/IMP, KPC, NDM).
Results: 184 rectal samples were collected. The overall carriage rate of CRE was 6% (KPC and NDM in 73% and 27% patients, respectively). Seventy-two patients with positive rectal swabs showed almost one of the following features: hospitalization/antibiotics in the last month, haemodialysis. In our cohort positivity rate of urine and blood cultures was 5% and 16% respectively. No correlation between CRE colonization and urine positivity was found; 18% patients showed both blood cultures and rectal swab positive and died. Mortality rate in patients with positive blood cultures and negative rectal swab was 33%.
Conclusions: the number of positive rectal swabs compared to the total number of hospitalized patients remained low thanks to the procedures adopted after identification of carriers. Colonization increases the risk of infection by multidrug-resistant bacteria, having a remarkable impact on prognosis (as we observed mortality up to 100% in patient with blood culture and rectal swab positive).
Altmetrics
Downloads
Citations
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.