Original Articles
10 June 2025
Vol. 19 No. 2 (2025)
The role of the neutrophil-to-lymphocyte ratio and the platelet-to-lymphocyte ratio in assessing hypothyroidism Hashimoto’s thyroiditis
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
664
Views
147
Downloads
31
HTML
Authors
Hashimoto’s thyroiditis (HT) is the most prevalent autoimmune thyroid disorder, influenced by genetic predispositions, environmental factors, and immune dysfunction. High iodine intake has been identified as a potential trigger in susceptible individuals. This study investigates the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) as inflammatory markers in patients with hypothyroid HT. Conducted at Thumbay Labs in Ajman, United Arab Emirates, this cross-sectional study involved 150 participants, including 100 diagnosed with hypothyroid HT and 50 healthy controls. Significant differences were found in the mean values of free thyroxine (FT4), thyroid-stimulating hormone (TSH), NLR, PLR, and anti-thyroid peroxidase (ATPO) between the patient and control groups (p<0.05). Specifically, mean values were 0.02 for FT4, 0.00 for TSH, 0.000 for NLR, 0.02 for PLR, and 0.01 for ATPO. Gender did not significantly influence these metrics. The results indicate elevated NLR and reduced PLR in hypothyroid HT patients, suggesting their potential utility as cost-effective inflammatory markers in clinical settings. Nevertheless, due to contradictory findings in existing literature, further research is necessary to validate NLR and PLR’s roles in managing HT, which may enhance patient care strategies.
Altmetrics
Downloads
Download data is not yet available.
Citations
Mincer DL, Jialal I. Hashimoto thyroiditis. Treasure Island, FL, USA: StatPearls Publishing; 2025.
Tamaki S, Nagai Y, Shutta R, et al. Combination of neutrophil‐to‐lymphocyte and platelet‐to‐lymphocyte ratios as a novel predictor of cardiac death in patients with acute decompensated heart failure with preserved left ventricular ejection fraction: a multicenter study. J Am Heart Assoc 2023;12:e026326. DOI: https://doi.org/10.1161/JAHA.122.026326
Altoum AEA, Osman AL, Babker AM. Impact of body mass index in malondialdehyde, antioxidant vitamins A, E, C and plasma zinc among type 2 diabetic patients. Kuwait Med J 2019;51:16-20.
Hatem M, Abbas AM, Huneif MA, et al. Influence of Ramadan fasting on hemoglobin A1C, lipid profile, and body mass index among type 2 diabetic patients in Najran City, Saudi Arabia. Open Access Maced J Med Sci 2021;9:318-25. DOI: https://doi.org/10.3889/oamjms.2021.6084
Pan L, Du J, Li T, Liao H. Platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio associated with disease activity in patients with Takayasu's arteritis: a case-control study. BMJ Open 2017;7:e014451. DOI: https://doi.org/10.1136/bmjopen-2016-014451
Bilge M, Yesilova A, Adas M, Helvaci A. Neutrophil- and platelet- to lymphocyte ratio in patients with euthyroid Hashimoto’s thyroiditis. Exp Clin Endocrinol Diabetes 2019;127:545-9. DOI: https://doi.org/10.1055/a-0723-3441
Resber HN, Takir M, Torun C. Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in the patients with euthyroid Hashimoto's thyroiditis. Medeni Med J 2023;38:204-9. DOI: https://doi.org/10.4274/MMJ.galenos.2023.41882
Özsu E, Mutlu RGY, Çizmeci F, Hatun Ş. Characteristics of our patients with Hashimoto thyroiditis. Turk Pediatr Ars 2011;46:244-7. DOI: https://doi.org/10.4274/tpa.46.83
Erbaş İC, Erbaş İM, Evliyaoğlu O. Clinical, biochemical, and radiological follow-up results of children and adolescents with Hashimoto’s thyroiditis: a single-center experience. J Pediatr Endocrinol Metab 2021;34:987-94. DOI: https://doi.org/10.1515/jpem-2021-0035
Mohamedahmed KA, Mubarak MO, Abdebagi A, et al. Assessment of red cell distribution width among Sudanese patients with subclinical hypothyroidism. Int J Biomed 2023;13:229-33. DOI: https://doi.org/10.21103/Article13(2)_OA4
Demir AD. Relationship of the platelet distribution width/platelet count ratio with thyroid antibody levels in patients with Hashimoto’s thyroiditis. J Int Med Res 2021;49:3000605211043241. DOI: https://doi.org/10.1177/03000605211043241
Hu ZD, Sun Y, Guo J, et al. Red blood cell distribution width and neutrophil/lymphocyte ratio are positively correlated with disease activity in primary Sjögren syndrome. Clin Biochem 2014;47:287-90. DOI: https://doi.org/10.1016/j.clinbiochem.2014.08.022
Gonzalez-Diaz SN, Sanchez-Borges M, Rangel-Gonzalez DM, et al. Chronic urticaria and thyroid pathology. World Allergy Organ J 2020;13:100101. DOI: https://doi.org/10.1016/j.waojou.2020.100101
Guo Q, Wu Y, Hou Y. Cytokine secretion and pyroptosis of thyroid follicular cells mediated by enhanced NLRP3, NLRP1, NLRC4, and AIM2 inflammasomes are associated with autoimmune thyroiditis. Front Immunol 2018;9:1197. DOI: https://doi.org/10.3389/fimmu.2018.01197
Ragusa F, Fallahi P, Elia G, et al. Hashimotos’ thyroiditis: epidemiology, pathogenesis, clinic and therapy. Best Pract Res Clin Endocrinol Metab 2019;33:101367. DOI: https://doi.org/10.1016/j.beem.2019.101367
Marwaha RK, Tandon N, Karak AK, et al. Hashimoto’s thyroiditis: countrywide screening of goitrous healthy young girls in postiodization phase in India. J Clin Endocrinol Metab 2000;85:3798-802. DOI: https://doi.org/10.1210/jc.85.10.3798
Guvendi B, Kara F, Guvendi FG, et al. The effect of Hashimoto’s thyroiditis on platelets in terms of the their number, size, and distribution. Dicle Med J 2019;46:277-81. DOI: https://doi.org/10.5798/dicletip.574791
Findikli HA, Tutak AS. Evaluation of the platelet indices in patients with subclinical hypothyroidism. Arch Clin Biomed Res 2018;2:227-32.
Önalan E, Dönder E. Neutrophil and platelet to lymphocyte ratio in patients with hypothyroid hashimoto’s thyroiditis. Acta Biomed 2020;91:310-4.
How to Cite
The role of the neutrophil-to-lymphocyte ratio and the platelet-to-lymphocyte ratio in assessing hypothyroidism Hashimoto’s thyroiditis. (2025). Italian Journal of Medicine, 19(2). https://doi.org/10.4081/itjm.2025.1953
Copyright (c) 2025 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Francesco Rondoni, Giorgio Simonelli, Pietro Maria Lunghi, Francesco Rossetti, Luciano Bondi, Institutionalized elderly people and malnutrition: research on the patients of a nursing home , Italian Journal of Medicine: Vol. 7 No. 3 (2013)
- Sirio Fiorino, Andrea Carusi, Alessandro Zappi, Fabio Tateo, Luca Peruzzo, Melissa Zanardi, Francesco Savelli, Giulia Di Marzio, Silvia Cesaretti, Francesca Dazzani, Raffaella Francesconi , Paolo Leandri , Gianfranco Tortorici , Susanna Vicari , Dora Melucci, Federico Lari, Characteristics, comorbidities and laboratory measures associated with disease severity and poor prognosis in young and elderly patients with COVID-19 admitted to medical wards in Emilia-Romagna region, Italy: a multicentre retrospective study , Italian Journal of Medicine: Vol. 17 No. 1 (2023)
- Raffaele Natale, Luca Maria Capece, Sofia Donnarumma, Pasquale Madonna, Carolina Bologna, Domenico Birra, Antonietta De Sena, Marina Lugarà, Claudio De Luca, Mariavittoria Guerra, Gabriella Oliva, Fabio Granato Corigliano, Paolo Tirelli, Vincenzo Nuzzo, Patent foramen ovale and stroke: a possible association with deep vein thrombosis , Italian Journal of Medicine: Vol. 18 No. 4 (2024)
- Francesco Serafini, Giuseppe Fantin, Roberto Brugiolo, Onofrio Lamanna, Anna Aprile, Fabio Presotto, Outlier admissions of medical patients: prognostic implications of outlying patients. The experience of the Hospital of Mestre , Italian Journal of Medicine: Vol. 9 No. 3 (2015)
- Mauro Campanini, Eleonora Rizzi, Thomas Fleetwood, Giuliano Pinna, Greta Maria Giacomini, Acetylsalicylic acid in primary prevention: a review , Italian Journal of Medicine: Vol. 18 No. 3 (2024)
- Giuseppe Di Pasquale, Gloria Vassilikì Coutsoumbas, Silvia Zagnoni, Inappropriate testing for the diagnosis of coronary artery disease , Italian Journal of Medicine: Vol. 9 No. 3 (2015)
- Manuel Monti, Valeria Mommi, Maria Beatrice Forte, Francesco Paciullo, Francesca Francavilla, Francesco Borgognoni, Olanzapine-associated hypothermia: a case report of a rare event , Italian Journal of Medicine: Vol. 12 No. 1 (2018)
- Luca Masotti, Rinaldo Innocenti, Stefano Spolveri, Irene Chiti, Grazia Panigada, Cristiana Seravalle, Giancarlo Landini, Alberto Fortini, Rino Migliacci, Raffaele Laureano, for Tuscan FADOI Stroke Registry Investigators, Stroke prevention in atrial fibrillation: findings from Tuscan FADOI Stroke Registry , Italian Journal of Medicine: Vol. 9 No. 2 (2015)
- Livio Bonsignore, Roberto Cardillo, Salvatore Leotta, Sebastiano Pavone, Alfonsa Lucia Dimora, Irene Alfina Cavallaro, Rosaria Platania, Nunzio Maurizio Catania, Rocco Siciliano, Adult onset Still's disease: a comparison of two clinical cases , Italian Journal of Medicine: Vol. 7 No. 4 (2013)
- Andrea Montagnani, Laura Morbidoni, Tiziana Attardo, Davide Brancato, Maurizia Gambacorta, Alberto Grassi, Ada Maffettone, Roberta Re, Daniela Tirotta, Mauro Campanini, for the FADOI Permanent Area of Clinical Governance, The discharge of patients with diabetes from Internal Medicine Units: a clinical audit , Italian Journal of Medicine: Vol. 9 No. 2 (2015)
You may also start an advanced similarity search for this article.