Case Reports
Vol. 18 No. 2 (2024)
Acquired hemophilia A in a case of purple urine bag syndrome
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Received: 5 March 2024
Accepted: 19 April 2024
Accepted: 19 April 2024
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The rare hemorrhagic disorder known as acquired hemophilia A (AHA) is brought on by the spontaneous development of autoantibodies against coagulation factor VIII (FVIII). It may be secondary to autoimmune diseases or cancers, or it may be idiopathic. Less than 10% of cases may have an infection as a secondary cause. We present the case of a 90-year-old anemic woman who was admitted to the hospital. She contracted a urinary tract infection (UTI) while in the hospital, and her urine took on a distinct purple hue. She had poor hemorrhagic manifestations and a prolonged partial thromboplastin time. After ruling out autoimmune and neoplastic causes, we diagnosed AHA as a result of a UTI caused by Enterococcus faecalis.
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Citations
Mazzucconi MG, Baldacci E, Ferretti A, Santoro C. Acquired haemophilia A: an intriguing disease. Mediterr J Hematol Infect Dis 2020;12:e2020045.
Sabanis N, Paschou E, Papanikolaou P, Zagkotsis G. Purple urine bag syndrome: more than eyes can see. Curr Urol 2019;13:125-32.
Tiede A, Collins P, Knoebl P, et al. International recommendations on the diagnosis and treatment of acquired hemophilia A. Haematologica 2020;105:1791-801.
Kruse-Jarres R, Kempton CL, Baudo F, et al. Acquired hemophilia A: updated review of evidence and treatment guidance. Am J Hematol 2017;92:695-705.
Kreuter M, Retzlaff S, Enser-Weis U, et al. Acquired haemophilia in a patient with gram-negative urosepsis and bladder cancer. Haemophilia 2005;11:181-5.
Yamamoto K, Niiya K, Shigematu T, et al. Transient factor VIII inhibitor in a hemophilia patient after staphylococcal septic shock syndrome. Int J Hematol 2000;72:517-9.
Laporte F, Cestac P, Favre V, et al. Traitement d'une hémophilie acquise chez un patient septique [Treatment of a septic patient with acquired haemophilia]. Rev Med Interne 2003;24:692-5.
Khan F, Chaudhry MA, Qureshi N, Cowley B. Purple urine bag syndrome: an alarming hue? A brief review of the literature. Int J Nephrol 2011;2011:419213.
Nandwani A, Jha PK, Gadde A, Jain M. Purple urine bag syndrome. Indian J Nephrol 2022;32:646-7.
How to Cite
Acquired hemophilia A in a case of purple urine bag syndrome. (2024). Italian Journal of Medicine, 18(2). https://doi.org/10.4081/itjm.2024.1713
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