Actinomyces turicensis: a peculiar case of empyema after COVID-19 in a patient with ulcerative colitis

Published: 9 May 2024
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Actinomyces species are recognized as common mucosal bacteria in humans and as a newly discovered source of infection. Since its discovery in 1995, the subspecies Actinomyces turicensis has been reported as the causative pathogen of numerous infections. Only two instances of A. turicensis-related empyema, however, have been documented in the literature as of late. We report a unique case of polymicrobial empyema caused by A. turicensis shortly after a COVID-19 without any clear risk factors for anaerobic aspiration, along with a brief review of the literature. Tetracycline was successfully used for the first time to treat A. turicensis empyema, following chest drainage.



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Valour F, Sénéchal A, Dupieux C, et al. Actinomycosis: etiology, clinical features, diagnosis, treatment, and management. Infect Drug Resist 2014;7:183-97. DOI:
Könönen E, Wade WG. Actinomyces and related organisms in human infections. Clin Microbiol Rev 2015;28:419-42. DOI:
Smego Jr RA, Foglia G. Actinomycosis. Clin Infect Dis 1998;26:1255-61. DOI:
Sabbe LJ, Van De Merwe D, Schouls L, et al. Clinical spectrum of infections due to the newly described Actinomyces species A. turicensis, A. radingae, and A. europaeus. J Clin Microbiol 1999;37:8-13. DOI:
Johnson SW, Billatos E. Polymicrobial empyema: a novel case of Actinomyces turicensis. Respir Med Case Rep 2021;32:101365. DOI:
Agrafiotis AC, Lardinois I. Pleural empyema caused by Actinomyces turicensis. New Microbes New Infect 2021;41:100892. DOI:
Russo TA. Agents of actinomycosis. In: Principles and practice of infectious disease. 5th edition. Mandell GL (eds.). Philadelphia: Elsevier, Churchill Livingstone; 1995:2645-54.
Kim SR, Jung LY, Oh IJ, et al. Pulmonary actinomycosis during the first decade of 21st century: cases of 94 patients. BMC Infect Dis 2013;13:216. DOI:
Mabeza GF, Macfarlane J. Pulmonary actinomyces. Eur Respir J 2003;21:545-51. DOI:
Hall V, Talbot PR, Stubbs SL, Duerden BI. Identification of clinical isolates of Actinomyces species by amplified 16S ribosomal DNA restriction analysis. J Clin Microbiol. 2001;39:3555-62. DOI:
Hoheisel A, Herrmann MJ, Kassi E, et al. Actinomyces meyeri pleural empyema: a case report. IDCases 2021;26:e01278. DOI:
Cheon JE, Im JG, Kim MY, et al. Thoracic actinomycosis: CT findings. Radiology 1998;209:229-33. DOI:
Smith AJ, Hall V, Thakker B, Gemmell CG. Antimicrobial susceptibility testing of Actinomyces species with 12 antimicrobial agents. J Antimicrob Chemother 2005;56:407-9. DOI:
Steininger C, Willinger B. Resistance patterns in clinical isolates of pathogenic Actinomyces species. J Antimicrob Chemother 2016;71:422-7. DOI:
Hooper C, Lee YCG, Maskell N. Investigation of a unilateral pleural effusion in adults: British Thoracic Society Pleural Disease Guideline 2010. Thorax 2010;65:ii4-ii17- DOI:
Freire MP, Oliveira MS, Magri MMC, et al., HCFMUSP COVID-19 Study Group, Levin AS. Frequency and factors associated with hospital readmission after COVID-19 hospitalization: the importance of post-COVID diarrhea. Clinics (Sao Paulo). 2022;77:100061. DOI:
Guarin G, Lo KB, Bhargav R, et al. Factors associated with hospital readmissions among patients with COVID‐19: a single‐center experience. J Med Virol 2021;93:5582‐7. DOI:
Romero-Duarte Á, Rivera-Izquierdo M, Guerrero-Fernández de Alba I, et al. Sequelae, persistent symptomatology and outcomes after COVID-19 hospitalization: the ANCOHVID multicentre 6-month follow-up study. BMC Med 2021;19:129. DOI:
Topić MB, Desnica B, Vicković N, et al. The polymicrobial Actinomyces naeslundii and Pseudomonas aeruginosa sepsis in a patient with ulcerative colitis 2 months after colonoscopy. Wien Klin Wochenschr 2014;126:130-2. DOI:
Cunha F, Sousa DL, Trindade L, Duque V. Disseminated cutaneous Actinomyces bovis infection in an immunocompromised host: case report and review of the literature. BMC Infect Dis 2022;22:310. DOI:

How to Cite

Marzi, F., D’Errico, A., Alessandri, M., De Crescenzo, V., & Manini, M. (2024). <i>Actinomyces turicensis</i>: a peculiar case of empyema after COVID-19 in a patient with ulcerative colitis. Italian Journal of Medicine, 18(2).