Combined immunosuppressive treatment for giant cell myocarditis: a case report

Published: 9 February 2024
Abstract Views: 332
PDF: 226
HTML: 36
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.


Giant cell myocarditis (GCM) is a rare and often fulminant autoimmune disease. The immune-mediated pathogenesis of GCM is also supported by animal models, association with other immunological diseases and therapeutic efficacy of immunosuppressive drugs. The diagnosis of GCM is based on endomyocardial biopsy. GCM is an orphan disease. Heart transplantation is effective but up to 25% of transplanted patients experience disease recurrence. Immunosuppressive drugs have been shown to be potential therapeutic agents for GCM. In the present case report, the prescription of cyclosporine, azathioprine and prednisone resulted in a rapid and prolonged remission in support of the role of a combined immunosuppressive regimen in improving the long-term prognosis of this cardiac pathology.



PlumX Metrics


Download data is not yet available.


Xu J, Brooks EG. Giant cell myocarditis: a brief review. Arch Pathol Lab Med 2016;140:1429-34. DOI:
Kasouridis I, Majo J, MacGowan G, Clark AL. Giant cell myocarditis presenting with acute heart failure. BMJ Case Rep 2017; 2017: bcr-2017-219574. DOI:
Funaki T, Saji M, Murai T, et al. Combination Immunosuppressive Therapy for Giant cell myocarditis. Intern Med 2022;61:2895-98. DOI:
Tompkins R, Cole WJ, Rosenzweig BP, et al. Giant cell Myocarditis: not always a presentation of cardiogenic Shock. Case Rep Cardiol 2015;2015:173826. DOI:
Liu S, Zheng L, Shen L, et al. Clinical Identification and Characteristic Analysis of Giant Cell Myocarditis in 12 Cases. Front Cardiovasc Med 2021;8:649094. DOI:

How to Cite

Iebba, F., Bottari, V. E., Di Sora, F., Mallus, M. T., Manfredi, R. M., & Prati, F. (2024). Combined immunosuppressive treatment for giant cell myocarditis: a case report. Italian Journal of Medicine, 18(1).