Outcomes of patients with COVID-19 hospitalized during the fourth pandemic wave in relation to their clinical features and vaccination status

Submitted: 28 October 2022
Accepted: 13 December 2022
Published: 30 December 2022
Abstract Views: 1599
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This study aims to observe the clinical characteristics and outcomes of recovered patients from coronavirus disease 2019 (COVID-19) related to the vaccination status. We examined results of 205 COVID-19-recovered patients from 15 December 2021 to 1 March 2022 in two hospitals of Local Health Authority of Alessandria (Italy) during the fourth pandemic wave. 77% of patients were hospitalized for acute respiratory failure (ARF) with radiological pneumonia pattern (recovered for COVID), 23% for other causes with occasional positivity finding (recovered with COVID). 32% of patients were not vaccinated for SARS-CoV-2, 37% had three doses, 25% two doses, 5% only one dose. All patients without vaccination were hospitalized for ARF and they had a 7 times higher risk of hospitalization than the vaccinated. 60% of all patients had ≥3 comorbidities, of these 50% was vaccinated with three doses. In the fourth pandemic wave compared to the other not all patients were hospitalized for ARF and pneumonia and the presence of comorbidities ≥3 is a risk factor for hospitalization regardless of vaccination status. This justifies the administration of the fourth dose to frail patients.



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World Health Organization (WHO). Statement on the second meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV); 30 January 2020. Available from: https://www.who.int/news/item/30-01-2020-statement-on-the-second-meeting-of-the-international-health-regulations-(2005)-emergency-committeeregarding-the-outbreak-of-novel-coronavirus-(2019-ncov) Accessed: 27 April, 2020.
Ministero della Salute; Presidenza del Consiglio dei Ministri. Report vaccini anti COVID-19. Available from: https://www.governo.it/it/cscovid19/report-vaccini/

How to Cite

Crivellari, S., Pasquali, M., Aiosa, G., Daniele, A., Bertolotti, M., Salerno, C., Pacileo, G., Marchisio, S., Maconi, A., & Gnerre, P. (2022). Outcomes of patients with COVID-19 hospitalized during the fourth pandemic wave in relation to their clinical features and vaccination status. Italian Journal of Medicine, 16(1). https://doi.org/10.4081/itjm.2022.1541