Case Reports
7 March 2013
Vol. 5 No. 2 (2011)
https://doi.org/10.4081/itjm.2011.120

Agranulocytosis: an adverse effect of allopurinol treatment

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Allopurinol, Agranulocytosis, Hyperuricaemia.
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Authors

Elisa Mari
Franco Ricci
Davide Imberti
Massimo Gallerani
m.gallerani@ospfe.it
Introduction: Allopurinol is a xanthine oxidase inhibitor that is primarily used to treat hyperuricemia and its complications. The drug is rarely associated with adverse effects, but those that occur can be significant. Hematologic side effects, including bone marrow suppression, severe anemia, thrombocytopenia, and leukopenia, have been reported in 0.2-0.6% of treated patients.
Materials and methods: We report a case of agranulocytosis associated with allopurinol therapy in a patient admitted for fever.

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Agranulocytosis: an adverse effect of allopurinol treatment. (2013). Italian Journal of Medicine, 5(2), 120-123. https://doi.org/10.4081/itjm.2011.120

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