HIV, HCV and SARS-CoV-2: friends or foes? A case report

Submitted: 30 July 2020
Accepted: 9 February 2021
Published: 24 September 2021
Abstract Views: 831
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Data about co-infection of severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), HIV, and hepatitis C virus (HCV) are still scarce. We describe a patient hospitalized for sore throat, fatigue, and myalgia with a personal history of HIV and occult HBV infection. His antiretroviral therapy included bictegravir/emtricitabine/tenofovir alafenamide. The nasopharyngeal swab was positive for SARS-CoV-2 and laboratory testing showed acute HCV. Antiretroviral therapy was continued, but no specific therapy for SARS-CoV-2 was started. After 4 weeks, the nasopharyngeal swab resulted negative for SARS-CoV-2 and biochemical tests revealed undetectable HCV RNA with normalization of transaminases. To the best of our knowledge, this is the first reported case of acute HCV in a patient with HIV and SARS-CoV-2 co-infection.

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Citations

Zhao J, Liao X, Wang H, et al. Early virus clearance and delayed antibody response in a case of COVID-19 with a history of co-infection with HIV-1 and HCV. Clin Infect Dis 2020 [Epub ahead of print].
The Center for Systems Science and Engineering (CSSE) at Johns Hopkins University. Coronavirus COVID-19 global cases. Available from: https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6 Accessed: July 28, 2020.
Fu L, Wang B, Yuan T, et al. Clinical characteristics of coronavirus disease (COVID-19) in China: a systematic review and meta-analysis. J Infect 2020;80:656-65. DOI: https://doi.org/10.1016/j.jinf.2020.03.041
Blanco JL, Ambrosini J, Garcia F, et al. COVID-19 in patients with HIV: clinical case series, Lancet HIV 2020;7:e314-6. DOI: https://doi.org/10.1016/S2352-3018(20)30111-9
Riva A, Conti F, Bernacchia D, et al. Darunavir does not prevent SARS-CoV-2 infection in HIV patients. Pharmacol Res 2020;157:104826. DOI: https://doi.org/10.1016/j.phrs.2020.104826
HÓ“rter G, Spinner CD, Roider J, et al. COVID-19 in people living with human immunodeficiency virus: a case series of 33 patients. Infection 2020 [Epub ahead of print]. DOI: https://doi.org/10.1007/s15010-020-01438-z
Elfiky AA. Ribavirin, remdesivir, sofosbuvir, galidesivir, and tenofovir against SARS-CoV.2 RNA dependent RNA polymerase (RdRp): a molecular docking study. Life Sci 2020;25:117592. DOI: https://doi.org/10.1016/j.lfs.2020.117592
Vizcarra P, Perez-Elias MJ, Quereda C, et al. Description of COVID-19 in HIV-infected individuals: a single-centre, prospective cohort. Lancet HIV 2020 [Epub ahead of print]. DOI: https://doi.org/10.2139/ssrn.3588554
Sanduzzi A, Sanduzzi Zamparelli S. Nasopharyngeal and oropharyngeal swabs, and/or serology for SARS COVID-19: what we are looking for? Int J Environ Res Public Health 2020;17:3289. DOI: https://doi.org/10.3390/ijerph17093289
Zhang C, Shi L, Wang F-S. Liver injury in COVID-19: management and challenges. Lancet Gastroenterol Hepatol 2020 [Epub ahead of print]. DOI: https://doi.org/10.1016/S2468-1253(20)30057-1
American Association for the Study of Liver Diseases. Clinical insights for hepatology and liver transplant providers during the COVID-19 pandemic. Released: April 7, 2020. Available from: www.aasld.org
Kamal SM. Acute hepatitis C: a systematic review. Am J Gastroenterol 2008;103:1283-97. DOI: https://doi.org/10.1111/j.1572-0241.2008.01825.x
Izzi A, Messina A, Rinaldi L, et al. Editorial-Sofosbuvir/velpatasvir as a combination with strong potential activity against SARS-CoV2 (COVID-19) infection: how to use direct-acting antivirals as broad-spectrum antiviral agents. Eur Rev Med Pharmacol Sci 2020;24:5193-4.
Xiao C, Li X, Liu S, et al. HIV-1 did not contribute to the 2019-nCoV genome. Emerg Microb Infect 2020;9:379-81. DOI: https://doi.org/10.1080/22221751.2020.1727299

How to Cite

Garlatti Costa, E. ., Mazzaro, C., Grembiale, A., Berto, A., De Rosa, R. ., Grazioli, S., & Tonizzo, M. (2021). HIV, HCV and SARS-CoV-2: friends or foes? A case report. Italian Journal of Medicine, 15(3). https://doi.org/10.4081/itjm.2021.1350