Original Articles
24 September 2024
Vol. 18 No. 3 (2024)
https://doi.org/10.4081/itjm.2024.1784

Correlation between diet, body mass index, and lipid profile in Kosovar women treated for primary infertility

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Diet, BMI, infertility, obesity, lipidogram
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Authors

Fatjona Gashi
https://orcid.org/0009-0009-1200-3181
Faculty of Biotechnical Sciences, University St. Kliment Ohridski, Bitola, North Macedonia; Biolab Medical Laboratory, Pejë, Kosovo.
Muhamet Kadrija
muhamet.kadrija@uni-gjk.org
https://orcid.org/0009-0001-1521-8745
Department of Public Health and Infectious Diseases, Sapienza University, Rome, Italy; University of Gjakova “Fehmi Agani”, Gjakova, Kosovo.
Zafer Gashi
Biolab Medical Laboratory, Pejë; UBT College, Prishtina, Kosovo; Universum International College, Pristina, Kosovo.
Mila Arapcheska
Faculty of Biotechnical Sciences, University St. Kliment Ohridski, Bitola, North Macedonia.
Shkelzen Elezaj
Universum International College, Pristina; Outpatient clinic “UROMED”, Pejë; Regional Hospital “Mother Teresa”, Pejë, Kosovo.
Fitore Gashi
Biolab Medical Laboratory, Pejë; Family Medicine Center “Mother Teresa”, Klina, Kosovo.
Fitim Gashi
Biolab Medical Laboratory, Pejë, Kosovo.
Gentian Elezaj
Outpatient clinic “UROMED”, Pejë, Kosovo.
Liridon Elezaj
Regional Hospital “Mother Teresa”, Pejë, Kosovo.

The increasing prevalence of female fertility requires the identification of potentially modifiable factors and non-pharmacological treatments. There is strong evidence that healthy preconception dietary patterns of women of reproductive age have a beneficial effect on fertility. In accordance with the hypothesis, the aim of the study is to evaluate the influence of diet on overweight and obesity in infertile women as well as the correlation of serum lipid concentration by making a comparison between three observed groups with different body mass index (BMI). A total of 107 women who were treated for infertility were investigated. Diet and food pattern survey, BMI, and lipidogram determination from venous blood samples were carried out. The determination of lipidogram parameters was carried out by enzymatic colorimetric test with the COBAS INTEGRA 400 apparatus. From the total number of patients included in the study (107), infertile women with abnormal BMI accounted for 26.16%, while fertile women with normal BMI accounted for 73.83% (p<0.001). The total cholesterol value for groups with BMI>25 kg/m2 was 6.78 mmol/L (p=0.031). High triglycerides with increased BMI were observed (2.27 mmol/L versus 2.68 mmol/L) (p=0.028). Low-density lipoprotein-cholesterol had higher concentrations in obese women (n=28), and high-density lipoprotein-cholesterol had lower concentrations in women with BMI>25 km2 (p<0.05). Western dietary patterns of nutrition results in obesity and increased BMI values in infertile women. Increased BMI has a positive correlation with lipid profile in obese infertile women.

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Yasir N, Parveiq S, Tariq H, Fatima A. Laparoscopic findings of female infertility-a study of 186 cases ata teriary care hospital. Pak Armed Forces Med J 2014;64:304-7.
Sharique AA, Sharique M, Shah SW. Insight into female endocrine infertility and its relationship to body mass index. Ann Abbasi Shaheed Hosp Karachi Med Den Coll 2016;21:214-20.
BushnikT, Cook JL, Yuzpe AA, et al. Estimating the prevalence of infertility in Canada. Hum Reeprod 2012;27:738-46. DOI: https://doi.org/10.1093/humrep/der465
Wise LA, Wesselink AK, Tucker KL, et al. Dietary fat intake and fecundability in 2 preconception cohort studies. Am J Epidemiol 2018;187:60-74.
Chiu YH, Chavarro JE, Souter I. Diet and female fertility: doctor, what should I eat? Fertil Steril 2018;110:560-9. DOI: https://doi.org/10.1016/j.fertnstert.2018.05.027
Sanderman EA, Willis SK, Wise LA. Female dietary patterns and outcomes of in vitro fertilization (IVF): a systematic literature review. Nutr J 2022;21:5. DOI: https://doi.org/10.1186/s12937-021-00757-7
Gürbüz T. A comprehensive survey: prevention of female infertility by nutrition. J Health Sci Med 2023;6:845-51. DOI: https://doi.org/10.32322/jhsm.1291555
Wade GN, Jones JE. Neuroendocrinology of nutritional infertility. Am J Physiol Regul Integr Comp Physiol 2004;287:R1277-96. DOI: https://doi.org/10.1152/ajpregu.00475.2004
Sutton ML, Gilchrist RB, Thompson JG. Effects of in-vivo and in-vitro environments on the metabolism of the cumulus-oocyte complex and its influence on oocyte developmental capacity. Hum Reprod Update 2003;9:35-48. DOI: https://doi.org/10.1093/humupd/dmg009
Rich-Edwards JW, Goldman MB, Willett WC, et al. Adolescent body mass index and infertility caused by ovulatory disorder. Am J Obstetr Gynecol 1994;171:171-7. DOI: https://doi.org/10.1016/0002-9378(94)90465-0
Kappeler L. Role of adipose tissue microRNAs in the onset of metabolic diseases and implications in the context of the DOHaD. Cells 2022;11:3711. DOI: https://doi.org/10.3390/cells11233711
Bond ST, Calkin AC, Drew BG. Adipose-derived extracellular vesicles: systemic messengers and metabolic regulators in health and disease. Front Physiol 2022;13:837001. DOI: https://doi.org/10.3389/fphys.2022.837001
Sharma G, Woods CD, Rajkarnikar R, et al. LBODP005 gper modulates multiple functions in adipose tissue to promote an anti-obese phenotype. J Endocrine Soc 2022;6:A3. DOI: https://doi.org/10.1210/jendso/bvac150.005
Al-Hakmani FM, Al-Fadhil FA, Al-Balushi LH, et al. The effect of obesity on pregnancy and its outcome in the population of Oman, seeb province. Oman Med J 2016;31:12-7. DOI: https://doi.org/10.5001/omj.2016.03
Pascuali N, Scotti L, Di Pietro M, et al. Ceramide-1- phosphate has protective properties against cyclophosphamide-induced ovarian damage in a mice model of premature ovarian failure. Hum Reprod 2018;33:844-59. DOI: https://doi.org/10.1093/humrep/dey045
Barrea L, Muscogiuri G, Pugliese G, et al. Metabolically healthy obesity (MHO) vs. metabolically unhealthy obesity (MUO) phenotypes in PCOS: association with endocrine-metabolic profile, adherence to the mediterranean diet, and body composition. Nutrients 2021;13:3925. DOI: https://doi.org/10.3390/nu13113925
Bright K, Dube L, Hayden KA, Gordon JL. Effectiveness of psychological interventions on mental health, quality of life and relationship satisfaction for individuals and/or couples undergoing fertility treatment: a systematic review and meta-analysis protocol. BMJ Open 2020;10:e036030. DOI: https://doi.org/10.1136/bmjopen-2019-036030
Bourrion B, Panjo H, Bithorel PL, et al. The economic burden of infertility treatment and distribution of expenditures overtime in France: a self-controlled pre-post study. BMC Health Serv Res 2022;22:512. DOI: https://doi.org/10.1186/s12913-022-07725-9
Ennab F, Atiomo W. Obesity and female infertility. Best Pract Res Clin Obst Gynaecol 2023;89:102336. DOI: https://doi.org/10.1016/j.bpobgyn.2023.102336
Chen CI, Hsu MI, Lin SH, et al. Adiponectin and leptin in overweight/obese and lean women with polycystic ovary syndrome. Gynecological Endocrinol 2015;31:264-8. DOI: https://doi.org/10.3109/09513590.2014.984676
Nair NB, Skaria M, Kumar RS. Female obesity: a probable cause of infertility. J Drug Delivery Ther 2022;12:216-20. DOI: https://doi.org/10.22270/jddt.v12i4.5585
Zander-Fox DL, Henshaw R, Hamilton H, Lane M. Does obesity really matter? The impact of BMI on embryo quality and pregnancy outcomes after IVF in women aged ≤38 years. Aust New Z J Obstet Gynaecol 2012;52:270-6. DOI: https://doi.org/10.1111/j.1479-828X.2012.01453.x
Dallel S, Tauveron I, Brugnon F, et al. Liver X receptors: a possible link between lipid disorders and female infertility. Int J Mol Sci 2018;19:2177. DOI: https://doi.org/10.3390/ijms19082177
Stouffer RL, Xu F, Duffy DM. Molecular control of ovulation and luteinization in the primate follicle. Front Biosci 2007;12:297-307. DOI: https://doi.org/10.2741/2065
Willnow TE, Hammes A, Eaton S. Lipoproteins and their receptors in embryonic development: more than cholesterol clearance. Development 2007;134:3239-49. DOI: https://doi.org/10.1242/dev.004408
World Health Organization. (‎2021)‎. WHO laboratory manual for the examination and processing of human semen, 6th ed. World Health Organization. https://iris.who.int/handle/10665/343208. License: CC BY-NC-SA 3.0 IGO.
OECD/World Health Organization (2020), “Overweight and obesity”, in Health at a Glance: Asia/Pacific 2020: Measuring Progress Towards Universal Health Coverage, OECD Publishing, Paris. DOI: https://doi.org/10.1787/a47d0cd2-en. DOI: https://doi.org/10.1787/a47d0cd2-en
Dobiásová M. AIP-atherogenic index of plasma as a significant predictor of cardiovascular risk: from research to practice. Vnitr Lek 2006;52:64-71. [Article in Czech].
Dobiásová M, Frohlich J. The plasma parameter log (TG/HDL-C) as an atherogenic index: correlation with lipoprotein particle size and esterification rate in apoB-lipoprotein-depleted plasma (FER(HDL)). Clin Biochem 2001;34:583-8. DOI: https://doi.org/10.1016/S0009-9120(01)00263-6
PSC Prospective Studies Collaboration. Body-mass index and cause-specific mortality in 900000 adults: collaborative analyses of 57 prospective studies. Lancet 2009;373:1083-96. DOI: https://doi.org/10.1016/S0140-6736(09)60318-4
Wise LA, Wesselink AK, Tucker KL, et al. Dietary fat intake and fecundability in 2 preconception cohort studies. Am J Epidemiol 2018;187:60-74. DOI: https://doi.org/10.1093/aje/kwx204
Lila A. Impact of obesity on ovarian reserve. 2019. Available from: https://urn.nsk.hr/urn:nbn:hr:105:121059.
van der Steeg JW, Steures P, Eijkemans MJ, et al. Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women. Hum Reprod 2008;23:324-8. DOI: https://doi.org/10.1093/humrep/dem371
Bagordo F, Grassi T, Serio F, et al. Dietary habits and health among university students living at or away from home in Southern Italy. J Food Nutr Res 2013;52:164-71.
Ginawi IA, Bashir AI, Alreshidi YQ, et al. Association between obesity and cigarette smoking: a community-based study. J Endocrinol Metabol 2016;6:149-53. DOI: https://doi.org/10.14740/jem378e
Wu S, Zhang X, Zhao X, et al. Preconception dietary patterns and associations with IVF outcomes: an ongoing prospective cohort study. Front Nutr 2022;9:808355. DOI: https://doi.org/10.3389/fnut.2022.808355
Hu FB. Dietary pattern analysis: a new direction in nutritional epidemiology. Curr Opin Lipidol 2002;13:3-9. DOI: https://doi.org/10.1097/00041433-200202000-00002
Gaskins AJ, Nassan FL, Chiu YH, et al. Dietary patterns and outcomes of assisted reproduction. Am J Obstet Gynecol 2019;220:567.e1-18. DOI: https://doi.org/10.1016/j.ajog.2019.02.004
Abiemo EE, Alonso A, Nettleton JA, et al. Relationships of the Mediterranean dietary pattern with insulin resistance and diabetes incidence in the multi-ethnic study of atherosclerosis (MESA). Br J Nutr 2013;109:1490-7. DOI: https://doi.org/10.1017/S0007114512003339
Safdar R. To study the effect of high intake of bakery products in causing obesity among students. EC Nutrition 2019;14-10:829-51.
Saremi A, Moradzadeh R. The relationship between physical activity and primary infertility in Iranian women. Women Health Bull 2024;11:20-8.
Li X, Ding W, Liu J, et al. Effects of dyslipidemia on IVF/ICSI pregnancy outcome in patients with polycystic ovary syndrome. Zhonghua Fu Chan Ke Za Zhi 2018;53:402-8. [Article in Chinese].
Tehrani FR, Erfani H, Cheraghi L, et al. Lipid profiles and ovarian reserve status: a longitudinal study. Hum Reprod 2014;29:2522-9. DOI: https://doi.org/10.1093/humrep/deu249
Kanthe PS, Patil BS, Bagali S, et al. Atherogenic index as a predictor of cardiovascular risk among women with different grades of obesity. Int J Collab Res Intern Med Public Health 2012;4:1767-74.
Zain MM, Norman RJ. Impact of obesity on female fertility and fertility treatment. Womens Health 2008;4:183-94. DOI: https://doi.org/10.2217/17455057.4.2.183
Abdessalem H, Demmouche A. A case-control study of body mass index and infertility in Algerian women (Sidi Bel Abbes, west of Algeria). Int J Infertility Fetal Med 2012;6:103-7. DOI: https://doi.org/10.5005/jp-journals-10016-1110
Liu T, Qu J, Tian M, et al. Lipid metabolic process involved in oocyte maturation during folliculogenesis. Front Cell Dev Biol 2022;10:806890. DOI: https://doi.org/10.3389/fcell.2022.806890
Zhu X, Hong X, Wu J, et al. The association between circulating lipids and female infertility risk: a univariable and multivariable mendelian randomization analysis. Nutrients 2023;15:3130. DOI: https://doi.org/10.3390/nu15143130
Lupattelli G, Marchesi S, Lombardini R, et al. Mechanisms of high-density lipoprotein cholesterol effects on the endothelial function in hyperlipemia. Metabolism 2003;52:1191-5. DOI: https://doi.org/10.1016/S0026-0495(03)00157-4

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Correlation between diet, body mass index, and lipid profile in Kosovar women treated for primary infertility. (2024). Italian Journal of Medicine, 18(3). https://doi.org/10.4081/itjm.2024.1784
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