https://doi.org/10.4081/itjm.2024.1717

Strong association between angiotensin I-converting enzyme insertion/deletion polymorphism and unexplained recurrent spontaneous abortion of Sudanese women: a case-control study

Vol. 18 No. 2 (2024)
Published: 4 April 2024
Spontaneous abortion, polymorphism, pregnancy loss, angiotensin converting enzyme
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Authors

Asaad M.A. Babker
asaad@gmu.ac.ae
Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates.
Hanan Khalid Fadul Ahmed
Department of Epidemiology, Tropical Medicine Research Institute, National Center for Research, Khartoum, Sudan.
Rania Saad Suliman
Department of Clinical Laboratory Sciences, Prince Sultan Military College for Health Sciences, Dhahran, Saudi Arabia.
Ahmed Luay Osman
Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates.
Ayman Hussien Alfeel
Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates.
Praveen Kumar Kandakurti
College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates.
Salaheldein G. Elzaki
Department of Epidemiology, Tropical Medicine Research Institute, National Center for Research, Khartoum, Sudan.

This study investigated the link between angiotensin I-converting enzyme insertion/deletion (ACE I/D) polymorphism and unexplained spontaneous abortion. This retrospective analytical case-control was conducted at the Omdurman Maternity Hospital in Sudan. The current study contained 230 individuals, including 119 cases (women who had at least three abortions) of unknown cause and 119 controls (healthy women who had at least two full-term deliveries without spontaneous abortion). Patients and controls were provided five ml of ethylenediaminetetraacetic acid blood and answered questionnaires about their demographics, personal lives, and family histories. ACE I/D polymorphisms were assessed using a conventional polymerase chain reaction approach after total genomic DNA was isolated from blood leukocytes using the GF-1 blood DNA extraction kit. Data was analyzed using the Statistical Package for the Social Sciences version 24. ACE I/D polymorphism is strongly linked to unexplained spontaneous abortion, and women with the I/D and D/D genotypes are more likely to have it than those with the I/I genotype. The current study reveals that ACEI/D polymorphism increases pregnancy problems. Sudanese women may have spontaneous abortions due to the ACE I/D polymorphism.

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How to Cite

Babker, A. M., Fadul Ahmed, H. K., Suliman, R. S., Osman, A. L., Alfeel, A. H., Kandakurti, P. K., & Elzaki, S. G. (2024). Strong association between angiotensin I-converting enzyme insertion/deletion polymorphism and unexplained recurrent spontaneous abortion of Sudanese women: a case-control study. Italian Journal of Medicine, 18(2). https://doi.org/10.4081/itjm.2024.1717
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