Case Reports
Vol. 17 No. 3 (2023)
https://doi.org/10.4081/itjm.2023.1619

Autoimmune hepatitis with eosinophilic infiltration responsive to anti-interleukin-5 receptor treatment: a case report and literature review

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Published: 31 October 2023
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Eosinophil, autoimmune hepatitis, severe eosinophilic asthma, interleukin-5, benralizumab

Authors

Francesca Romana Ponziani
Division of Internal Medicine and Gastroenterology, Hepatology Unit, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Cristiano Caruso
https://orcid.org/0000-0001-7631-029X
UOSD DH Internal Medicine and Gastroenterology, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Ilaria Baglivo
ilaria.baglivo@outlook.it
https://orcid.org/0000-0003-4041-5182
CEMAD Digestive Diseases Center, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Francesco Macagno
Complex Operational Unit of Pulmonology, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Antonio Gasbarrini
CEMAD Digestive Diseases Center, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Francesco Santopaolo
https://orcid.org/0000-0002-1773-1171
Division of Internal Medicine and Gastroenterology, Hepatology Unit, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Maria Cristina Giustiniani
Faculty of Medicine and Surgery, Institute of Pathological Anatomy, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Stefania Colantuono
https://orcid.org/0000-0002-8207-9837
UOSD DH Internal Medicine and Gastroenterology, Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.
Maurizio Pompili
Division of Internal Medicine and Gastroenterology, Hepatology Unit, Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Università Cattolica del Sacro Cuore, Rome, Italy.

Inflammatory tissue damage plays a role in the onset, progression, and exacerbation of various chronic autoimmune and metabolic diseases such as autoimmune hepatitis. Here we present a case of autoimmune hepatitis with liver eosinophilic infiltrate in a severe eosinophilic asthma patient who failed conventional immunosuppressive treatment and showed improvement in gastrointestinal symptoms after anti-interleukin-5 receptor treatment. Our case highlights the potential role of eosinophils in initiating or worsening liver inflammation in autoimmune liver disease. The link between eosinophilic inflammation, barrier damage, and chronic autoimmune diseases should be considered in clinical practice.

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Citations

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How to Cite



Autoimmune hepatitis with eosinophilic infiltration responsive to anti-interleukin-5 receptor treatment: a case report and literature review. (2023). Italian Journal of Medicine, 17(3). https://doi.org/10.4081/itjm.2023.1619
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