Reviews
19 March 2020
Vol. 14 No. 1 (2020)
https://doi.org/10.4081/itjm.2020.1185

Intestinal microbiota in the pathogenesis of chronic heart failure

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Intestinal microbiota, chronic heart failure, probiotics, cytokines.
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Authors

Vladimir Ivashkin
Internal Disease Propedeutics, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
Maria Fadeeva
Vasilenko Clinic of Internal Disease Propedeutics, Gastroenterology, and Hepatology, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
Manana Skhirtladze
Vasilenko Clinic of Internal Disease Propedeutics, Gastroenterology, and Hepatology, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
Oxana Zolnikova
ks.med@mail.ru
http://orcid.org/0000-0002-6701-789X
Internal Disease Propedeutics, I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.

In this review, we have considered and discussed the existing data to achieve a deeper understanding of the role of intestinal microbiota in the development and progression of chronic heart failure (CHF). The key moments of the CHF pathogenesis (an imbalance of neurohumoral systems, inflammatory theory and metabolic disorders) and the respective changes of the intestinal microflora composition were compared. Here, we also present the latest results of the positive influence of the microflora modulations on the course and prognosis of CHF with the prescribing antibiotics, probiotics and prebiotics.

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Intestinal microbiota in the pathogenesis of chronic heart failure. (2020). Italian Journal of Medicine, 14(1), 1-8. https://doi.org/10.4081/itjm.2020.1185

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