Original Articles
Vol. 9 No. 2 (2015)
https://doi.org/10.4081/itjm.2014.447

Study on distribution of Pro12Ala single nucleotide polymorphism of PPARγ2 gene in randomly sampled diabetic population from Guwahati city

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Received: 7 November 2013
Published: 24 September 2014
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Insulin metabolism, PPARγ2, Pro12Ala, basal metabolic index, mutation, obesity.
Medicine, India, North East

Authors

Navaneeta Majumdar
Department of Bioengineering and Technology, Gauhati University, Guwahati - 14, India.
Ananya Bhowmick
Department of Bioengineering and Technology, Gauhati University, Guwahati - 14, India.
Purabi Sarkar
Department of Bioengineering and Technology, Gauhati University, Guwahati - 14, India.
Rhituraj Doley
Department of Biological Sciences, Gauhati University, Guwahati - 14, India.
Indrajit Kalita
Shristi Diagnostics, Jonali, Guwahati - 24, India.
Subhash S. Medhi
Department of Biological Sciences, Gauhati University, Guwahati - 14, India.
Sofia Banu
sofiabanu2@gmail.com
Department of Bioengineering and Technology, Gauhati University, Guwahati - 14, India.
Diabetes is one of the most fatal and vastly heritable metabolic disorders across the globe primarily due to the associated long-term effects including uncontrolled blood sugar levels, blindness, renal and cardiac problems. One of the diabetes related genes peroxisome proliferated activated receptor gamma 2 (PPARγ2) plays significant role in insulin metabolism and is expressed predominantly in adipose tissues. Single nucleotide polymorphism (SNPs) like Pro12Ala, is known to be associated with PPARγ2 gene. In this study, we have made an effort to investigate the prevalence of Pro12Ala allele in the diabetic population of Guwahati, Assam. A total of 50 human subjects with control subjects were included in the study. The data obtained revealed that 49 out of 50 samples carried the Pro/Pro allele, while 1 individual carried the Pro/Ala allele. Results obtained in the study indicate the existence of insignificant link between the targeted SNP Pro12Ala and type 2 diabetes in the sampled population, whereas in contrast we found a strong association of the SNP Pro12Pro with diabetes. The present study shows that there is a need to carry out an extensive study with a large population, which would give us the better picture of occurrence of this SNP in Northeast Indian population.

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Gauhati University

How to Cite



Study on distribution of Pro12Ala single nucleotide polymorphism of PPARγ2 gene in randomly sampled diabetic population from Guwahati city. (2014). Italian Journal of Medicine, 9(2), 157-162. https://doi.org/10.4081/itjm.2014.447

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