The emerging role of whole-body 18F-fluorodeoxyglucose positron emission tomography in patients with sarcoidosis

  • Silvia Taralli Istituto di Medicina Nucleare (Direttore: Prof. Alessandro Giordano), Policlinico Gemelli, Università Cattolica del Sacro Cuore, Roma, Italy.
  • Giorgio Treglia | giorgiomednuc@libero.it Istituto di Medicina Nucleare (Direttore: Prof. Alessandro Giordano), Policlinico Gemelli, Università Cattolica del Sacro Cuore, Roma, Italy.
  • Alessandro Giordano Istituto di Medicina Nucleare (Direttore: Prof. Alessandro Giordano), Policlinico Gemelli, Università Cattolica del Sacro Cuore, Roma, Italy.

Abstract

Introduction

The purpose of this article is to examine the emerging role of whole-body positron emission tomography (PET) with 18F-fluorodeoxyglucose (FDG) in patients with sarcoidosis.

Materials and methods

We reviewed the literature on the use of FDG-PET in patients with sarcoidosis to identify how this technique is being applied in clinical practice.

Results and discussion

Our review shows that: 1) sarcoidosis is commonly associated with increased FDG uptake. Therefore, positive findings should be interpreted with caution when FDG-PET is being used to distinguish benign from malignant abnormalities; 2) FDG-PET seems to be a very useful molecular imaging method for staging sarcoidosis, identification of occult sites of involvement, guiding biopsy procedures, and monitoring patients’ responses to treatment; and 3) in patients with sarcoidosis, the diagnostic accuracy of FDG-PET is superior to that of 67Ga scintigraphy.

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Published
2012-01-30
Section
Reviews
Keywords:
Positron emission tomography, 18F-FDG, Sarcoidosis
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How to Cite
Taralli, S., Treglia, G., & Giordano, A. (2012). The emerging role of whole-body 18F-fluorodeoxyglucose positron emission tomography in patients with sarcoidosis. Italian Journal of Medicine, 6(1), 21-26. https://doi.org/10.4081/itjm.2012.21