Sitagliptin versus saxagliptin in decompensated type 2 diabetes mellitus patients

  • Antonio Asti Department of Clinical Medicine and Emergency, S. Maria di Loreto Nuovo Hospital, Napoli, Italy.
  • Alessandra D'Alessandro | alessa.dalessandro@gmail.com Department of Clinical Medicine and Surgery, Gastroenterology Unit, Federico II University, Napoli, Italy.
  • Francesco Paolo Zito Department of Clinical Medicine and Surgery, Gastroenterology Unit, Federico II University, Napoli, Italy.
  • Salvatore Nardi Department of Clinical Medicine and Emergency, S. Maria di Loreto Nuovo Hospital, Napoli, Italy.
  • Giovanni Sarnelli Department of Clinical Medicine and Surgery, Gastroenterology Unit, Federico II University, Napoli, Italy.
  • Giorgio Maresca Department of Clinical Medicine and Emergency, S. Maria di Loreto Nuovo Hospital, Napoli, Italy.
  • Giuseppe D’Alessandro Department of Clinical Medicine and Emergency, S. Maria di Loreto Nuovo Hospital, Napoli, Italy.

Abstract

Sitagliptin and saxagliptin are oral hypoglycemic agents inhibitors of DPP-4, indicated in the treatment of type 2 diabetes mellitus in combination with metformin, in patients who have not achieved adequate glycemic control. In our study we enrolled 128 decompensated type 2 diabetes patients while on metformin maximum dosage. At time 0’ we have detected, body mass index (BMI), total cholesterol, high- and low-density lipoproteins (HDL and LDL), triglycerides, transaminases and pancreatic amylase; patients were randomized to receive sitagliptin or saxagliptin; follow-up was performed after 4 months with the revaluation of the same variables and adverse events. In both sitagliptin and saxagliptin groups we observed a significant reduction in fasting glucose, glycated hemoglobin, weighing, BMI, triglycerides, while the reduction in total cholesterol, LDL cholesterol did not reach statistical significance. There was no suspension of therapy, adverse events appeared minor and temporary. In conclusion, our observations highlight the almost identical efficacy of sitagliptin and saxagliptin. These data reinforce even more the idea that we should think about this class of drugs as the next step in patients failing therapy with metformin.

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Published
2016-03-22
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Original Articles
Keywords:
Type 2 diabetes mellitus, sitagliptin, saxagliptin, DPP-4 inhibitors.
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How to Cite
Asti, A., D’Alessandro, A., Zito, F. P., Nardi, S., Sarnelli, G., Maresca, G., & D’Alessandro, G. (2016). Sitagliptin versus saxagliptin in decompensated type 2 diabetes mellitus patients. Italian Journal of Medicine, 10(1), 36-41. https://doi.org/10.4081/itjm.2016.558