Original Articles
Vol. 11 No. 4 (2017)
https://doi.org/10.4081/itjm.2017.819

Circadian blood pressure rhythm and intimal-medial thickness changes in non-dipper normotensive patients

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Received: 26 November 2016
Accepted: 11 February 2017
Published: 31 July 2017
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Normotensives, non-dipper, target organ damage, carotid intimal-medial thickness.
internal medicine

Authors

Massimiliano Rocchietti March
massimiliano.rocchietti@uniroma1.it
Geriatric Unit, Faculty of Medicine and Psychology, La Sapienza University, Roma, Italy.
Claudia Maggiore
Vascular Surgery Unit, Faculty of Medicine and Psychology, La Sapienza University, Roma, Italy.
Gerardo Salerno
Clinical Pathology Unit, Faculty of Medicine and Psychology, La Sapienza University, Roma, Italy.
Agostino De Venanzi
Endocrinology Unit, Faculty of Medicine and Psychology, La Sapienza University, Roma, Italy.
Elena Scaramucci
Clinical Pathology Unit, Faculty of Medicine and Psychology, La Sapienza University, Roma, Italy.
Patrizia Cardelli
Clinical Pathology Unit, Faculty of Medicine and Psychology, La Sapienza University, Roma, Italy.
We investigated 25 non-dipper normotensive vs 25 dipper normotensive patients. The aim of our study was to evaluate carotid intimal-medial thickness (IMT) in the two groups. At the admission patients underwent anamnesis and general examination, blood sampling for lipid profile measurement, glycemia, homocysteine, ambulatory blood pressure measurement to assess the circadian blood pressure profile, and Doppler ultrasound to measure carotid IMT. Our results showed that IMT is significantly higher in the non-dipper group (P<0.006) vs dippers. Non-dipper status has been recognized in several studies as a condition with increased risk for target organ damage in hypertensive and normotensive subjects. However, to our knowledge, a possible relationship between IMT and normotensive non-dipper patients has not yet been clearly investigated. Our study instead has clearly demonstrated a significant relationship between IMT and the non-dipper status.

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Circadian blood pressure rhythm and intimal-medial thickness changes in non-dipper normotensive patients. (2017). Italian Journal of Medicine, 11(4), 360-363. https://doi.org/10.4081/itjm.2017.819