P126 | Heart involvement in hypothyroidism: a myocardial work study
M. Pucci, V. Gammaldi, D. Paoletta, L.M. Capece, M. Pontoriero, S. Ruberto, F. Crescenzo, R. Esposito, B. Biondi | Department of Clinical Medicine and Surgery, Federico II University Hospital, Naples, Italy
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Introduction: From 2022 Guideline for Management of Heart Failure it’s known that hypothyroidism is a potential cause of heart failure.
Aim: Clarify the hemodynamic changes caused by hypothyroidism using myocardial work, an emerging echocardiographic tool.
Materials and Methods: Study population includes 48 patients with hypothyroidism in absence of cardiovascular risk factors and 102 healthy controls with euthyroidism. Myocardial work assessment was performed with EchoPAC. Four values are calculated: global work index (GWI), global constructive work (GCW), global wasted work (GWW) and global work efficiency (GWE). Continuous normally distributed variables were compared by using the Student t-test. Probability value <0.05 was considered significant.
Results: In hypothyroidism patients a significant increase in left ventricular mass indexed, a significant reduction in ejection fraction, a significant worsening of diastolic parameters were found; regarding myocardial work, a significant increase in GWW was found with a significant reduction in GWI, GCW and GWE. A comparison analysis was carried out in the group of hypothyroid patients subdividing them on the basis of TSH and showed a statistically significant reduction in GWE and increase in GWW in patients with TSH >10.
Conclusions: This study highlights how thyroid function plays a central role in regulating cardiac performance and the importance of early diagnosis and treatment of thyroid diseases in patients with heart failure.
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