CO35 | Changes in epidemiology of liver cirrhosis patients admitted to an Internal Medicine Unit from 2014 to 2023: a prospective analysis
M. Salvati1, V. Tommasi2, D. Manfellotto2, L. Carbone2, P. Piccolo2 | 1Medicina Interna, Università Campus Bio-Medico, Roma, 2Medicina Interna, Ospedale Isola Tiberina Gemelli-Isola, Roma, Italy
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Background: Metabolic-associated liver disease is increasing worldwide and end-stage liver disease is a frequent cause of admission to Internal Medicine (IM) Units. In this prospective study, we analyse the etiology and outcomes of admissions due to cirrhosis in a secondary hospital in Rome, Italy.
Methods: All admissions to IM during 2014-2023 were prospectively recorded along with demographic data, diagnosis, hospital stay and outcome. Patients with cirrhosis were retrospectively analysed for etiology, comorbidities, and clinical outcomes.
Results: 6932 admissions to IM from 2014 and 2023 were included; of these, 372 were due to cirrhosis (88% from the Emergency Department, 66.1% males, median age 71 years, IQR 23). Cirrhosis etiology was alcohol 45.4%, viral 44.3%, metabolic 17%, other 6.9%. Concomitant HCC was present in 24.7%; diabetes mellitus was present in 28% of cirrhotics. compared to 17.8% non-cirrhotics (p<0.001). Prevalence of viral etiology fell from 63% in 2014 to 41% in 2023 (p=0.04), while metabolic-associated cirrhosis increased from 6% in 2014 to 28% in 2023 (p=0.07). Mean hospital stay was 10.3±8 days and in-hospital mortality was 9.4% overall. Negative outcomes in cirrhotics (death, transfer to ICU, hospice care) fell from 26% in 2014 to 15.4% in 2023.
Conclusions: In the past 10 years, worldwide changes in etiology of chronic liver disease are evident among patients with cirrhosis admitted to IM. Cirrhotic patients have a higher prevalence of diabetes mellitus compared to other IM patients, reflecting the increasing burden of metabolic liver disease.
Altmetrics
Downloads
Citations
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.