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The effect of the antioxidant drug U-74389G on urea levels during ischemia reperfusion injury in rats

Constantinos Tsompos, Constantinos Panoulis, Konstantinos Toutouzas, Aggeliki Triantafyllou, George Zografos, Apostolos Papalois
  • Constantinos Panoulis
    Department of Obstetrics & Gynecology, Aretaieion Hospital, Athens University, Attiki, Greece
  • Konstantinos Toutouzas
    Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki, Greece
  • Aggeliki Triantafyllou
    Department of Biologic Chemistry, Athens University, Attiki, Greece
  • George Zografos
    Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki, Greece
  • Apostolos Papalois
    Experimental Research Centre, ELPEN Pharmaceuticals, S.A. Inc., Co., Athens, Greece

Abstract

This experimental study examined the effect of the antioxidant drug U-74389G, on a rat model and particularly in a renal ischemia- reperfusion protocol. The effects of that molecule were studied biochemically using blood mean urea levels. Forty rats of mean weight 231.875 g were used in the study. Urea levels were measured at 60 min of reperfusion (groups A and C) and at 120 min of reperfusion (groups B and D). The drug U-74389G was administered only in groups C and D. U-74389G administration significantly decreased the predicted urea levels by 11.35%±2.73% (P=0.0001). Reperfusion time non-significantly increased the predicted urea levels by 2.26%±3.29% (P=0.4103). However, U-74389G administration and reperfusion time together significantly decreased the predicted urea levels by 6.31%±1.70% (P=0.0005). U-74389G administration whether it interacted or not with reperfusion time had significant decreasing effect on the urea serum levels, reflecting a respective renal function augmentation.

Keywords

Ischemia; U-74389G; urea; reperfusion.

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Submitted: 2016-04-02 18:33:44
Published: 2017-05-30 00:00:00
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Copyright (c) 2017 Constantinos Τsompos, Constantinos Panoulis, Konstantinos Τοutouzas, Aggeliki Triantafyllou, George Ζografos, Apostolos Papalois

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