Italian Journal of Medicine <p>The <strong>Italian Journal of Medicine (ITJM)</strong> is the official journal of FADOI, the Federation of Associations of Hospital Doctors on Internal Medicine and focus to describe the complex and variable situations confronted by Internists in daily practice. ITJM aims to promote excellence in the practice of internal medicine in hospitals and to disseminate the results of clinical research in internal medicine departments. The journal also contributes to the updating of hospital internists on general topics concerning public health, including ethical, legal, economical and health policy issues. The <strong>Italian Journal of Medicine (ITJM)</strong> is a quarterly peer-reviewed journal aiming to publish highest-quality material covering original basic and clinical research on all aspects of internal medicine. The Journal includes original clinical research papers, reviews, case reports and specific sections dedicated to clinical pharmacology, chronic diseases, health management. The Italian Journal of Medicine is currently indexed in <a title="Scopus" href="" target="_blank" rel="noopener">Scopus</a> and <a title="DOAJ" href="" target="_blank" rel="noopener">DOAJ</a> since September 2009.</p> <p>This journal does not apply the article processing charge&nbsp;to Authors as it is supported by institutional funds.</p> PAGEPress Scientific Publications, Pavia, Italy en-US Italian Journal of Medicine 1877-9344 <p><strong>PAGEPress</strong> has chosen to apply the&nbsp;<a href="" target="_blank" rel="noopener"><strong>Creative Commons Attribution NonCommercial 4.0 International License</strong></a>&nbsp;(CC BY-NC 4.0) to all manuscripts to be published.<br><br> An Open Access Publication is one that meets the following two conditions:</p> <ol> <li>the author(s) and copyright holder(s) grant(s) to all users a free, irrevocable, worldwide, perpetual right of access to, and a license to copy, use, distribute, transmit and display the work publicly and to make and distribute derivative works, in any digital medium for any responsible purpose, subject to proper attribution of authorship, as well as the right to make small numbers of printed copies for their personal use.</li> <li>a complete version of the work and all supplemental materials, including a copy of the permission as stated above, in a suitable standard electronic format is deposited immediately upon initial publication in at least one online repository that is supported by an academic institution, scholarly society, government agency, or other well-established organization that seeks to enable open access, unrestricted distribution, interoperability, and long-term archiving.</li> </ol> <p>Authors who publish with this journal agree to the following terms:</p> <ol> <li>Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.</li> <li>Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.</li> <li>Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.</li> </ol> Comparison of aeroallergen sensitisation patterns in the United States and Europe <p>The global prevalence of allergic diseases have increased considerably and are a major socio-economic burden. Asthma is a complex disease and understanding asthma phenotypes and endotypes could eventually lead to individualised management, and offer better symptom control and quality of life. In this review, we first summarise the pathogenesis of atopic asthma and delve into the assessment of sensitisation to aeroallergens through skin prick testing and serological testing with total and specific immunoglobulin E testing. We will then analyse the distribution of aeroallergen sensitisation patterns in the United States and Europe and its effect on the population. This review gives a comprehensive overview on atopy and it compares the prevalence and effect of atopy within various regions of both continents using data from large multicentre studies. We will conclude this review by discussing the efficacy of add-on treatments in the most prevalent severe asthma phenotypes and endotypes.</p> Luca Conti Kelly Gatt Christopher Zammit Stephen Montefort David Bilocca ##submission.copyrightStatement## 2019-09-09 2019-09-09 13 3 10.4081/itjm.2019.1189 Gender differences in chronic obstructive pulmonary disease: Can be the DRG-based diagnosis the best way for a right analysis? <p>Not available</p> Antonello Nicolini Giancarlo Garuti Tommaso Perazzo Paolo Banfi Enrico Clini ##submission.copyrightStatement## 2019-09-06 2019-09-06 13 3 187 188 10.4081/itjm.2019.1175 An uncommon case of acute lower limb ischemia <p>We describe a case of a 76-year-old woman who presented to the Emergency Department with right lower limb pain after a fall. One hour after the admission to the Emergency Department, the patient presented all the signs and symptoms of acute limb ischemia. The patient underwent contrast-enhanced computed tomographic scan of abdomen and right lower limb that showed a large abdominal lesion suggestive of ovarian cancer compressing the right common iliac artery and a visible thrombus and ruptured plaque in this artery. We hypothesized that the acute limb ischemia caused by thrombosis<em> in situ</em> arose from acute plaque rupture probably due to the impact of the large abdominal mass on the artery during patient’s fall.</p> Maria Viviana Carlino Paola IeranĂ² Mario Venafro Claudia Sara Cimmino Costantino Mancusi Francesco Lassandro Pierluigi Angelini Alfonso Sforza Mario Guarino ##submission.copyrightStatement## 2019-09-06 2019-09-06 13 3 185 186 10.4081/itjm.2019.1131