Acute granulomatous interstitial nephritis and ulcerative colitis: a case report and literature review

Main Article Content

Giorgia Comai
Olga Baraldi
Vania Cuna
Valeria Corradetti
Maria Cappuccilli
Marco Busutti
Deborah Malvi
Benedetta Fabbrizio
Massimo Campieri
Gaetano La Manna *
(*) Corresponding Author:
Gaetano La Manna | gaetano.lamanna@unibo.it

Abstract

Tubulo-interstitial nephritis (TIN) in patients affected by inflammatory bowel disease, both ulcerative colitis and Crohn’s disease, is usually considered as drug-associated to aminosalicylate. We report a rare case of granulomatous active tubulo-interstitial nephritis in a young patient with a recent diagnosis of ulcerative colitis naïve to aminosalicylate treatment. The patient has been successfully treated with steroids administration. Our purpose is to sensitize that TIN should always to be considered in differential diagnosis an extra-intestinal manifestation of bowel disease.

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Author Biographies

Giorgia Comai, Department of Experimental Diagnostic and Specialty Medicine, Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna

Nephrologist

Olga Baraldi, Department of Experimental Diagnostic and Specialty Medicine, Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna

Nephrologist

Vania Cuna, Department of Experimental Diagnostic and Specialty Medicine, Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna

Nephrologist

Valeria Corradetti, Department of Experimental Diagnostic and Specialty Medicine, Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna

Nephrologist

Maria Cappuccilli, Department of Experimental Diagnostic and Specialty Medicine, Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna

Biochemist

Marco Busutti, Department of Experimental Diagnostic and Specialty Medicine, Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna

Specializing nephrologist

Deborah Malvi, Pathology Department, S. Orsola-Malpighi Hospital, University of Bologna, Bologna

Anatomopathologist

Benedetta Fabbrizio, Pathology Department, S. Orsola-Malpighi Hospital, University of Bologna, Bologna

Anatomopathologist

Massimo Campieri, Department of Clinical Medicine, S. Orsola Malpighi Hospital, University of Bologna, Bologna

Full Professor of Gastroenterology