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Acute granulomatous interstitial nephritis and ulcerative colitis: a case report and literature review

Giorgia Comai, Olga Baraldi, Vania Cuna, Valeria Corradetti, Maria Cappuccilli, Marco Busutti, Deborah Malvi, Benedetta Fabbrizio, Massimo Campieri, Gaetano La Manna
  • Giorgia Comai
    Department of Experimental Diagnostic and Specialty Medicine, Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
  • Olga Baraldi
    Department of Experimental Diagnostic and Specialty Medicine, Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
  • Vania Cuna
    Department of Experimental Diagnostic and Specialty Medicine, Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
  • Valeria Corradetti
    Department of Experimental Diagnostic and Specialty Medicine, Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
  • Maria Cappuccilli
    Department of Experimental Diagnostic and Specialty Medicine, Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
  • Marco Busutti
    Department of Experimental Diagnostic and Specialty Medicine, Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
  • Deborah Malvi
    Pathology Department, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
  • Benedetta Fabbrizio
    Pathology Department, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy
  • Massimo Campieri
    Department of Clinical Medicine, S. Orsola Malpighi Hospital, University of Bologna, Bologna, Italy
  • Gaetano La Manna
    Department of Experimental Diagnostic and Specialty Medicine, Nephrology, Dialysis and Renal Transplant Unit, S. Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy | gaetano.lamanna@unibo.it

Abstract

Tubulo-interstitial nephritis (TIN) in patients affected by inflammatory bowel disease, both ulcerative colitis and Crohn’s disease, is usually considered as drug-associated to aminosalicylate. We report a rare case of granulomatous active tubulo-interstitial nephritis in a young patient with a recent diagnosis of ulcerative colitis naïve to aminosalicylate treatment. The patient has been successfully treated with steroids administration. Our purpose is to sensitize that TIN should always to be considered in differential diagnosis an extra-intestinal manifestation of bowel disease.

Keywords

Aminosalicylate therapy; inflammatory bowel disease; tubulo-interstitial nephritis; steroid therapy.

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Submitted: 2017-09-16 08:29:00
Published: 2018-03-20 17:25:09
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Copyright (c) 2018 Giorgia Comai, Olga Baraldi, Vania Cuna, Valeria Corradetti, Maria Cappuccilli, Marco Busutti, Deborah Malvi, Benedetta Fabbrizio, Massimo Campieri, Gaetano La Manna

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